纳米氧化锌的肺毒性及机制研究进展  

Research progress in pulmonary toxicity and mechanisms of zinc oxide nanoparticles

作　　者：王皇斌 熊闽 黄莎莎 黄丽端 许秋凤 陈淑珍 WANG Huangbin;XIONG Min;HUANG Shasha;HUANG Liduan;XU Qiufeng;CHEN Shuzhen(Fujian Provincial Key Laboratory of Functional and Clinical Translational Medicine,Department of Basic Medicine,Xiamen 361023,China;Department of Pharmacy,Xiamen Medical College,Xiamen 361023,China)

机构地区：[1]厦门医学院基础医学部机能与临床转化福建省高校重点实验室,福建厦门361023 [2]厦门医学院药学系,福建厦门361023

出　　处：《中国药理学与毒理学杂志》2024年第11期880-886,共7页Chinese Journal of Pharmacology and Toxicology

基　　金：福建省自然科学基金(2021J01343);福建省大学生创新创业训练计划(S202212631003)。

摘　　要：纳米氧化锌具有多项优异性能,已逐步进入人们的生活。在日常接触中,纳米氧化锌能通过多种途径进入人体,并残留在组织器官中。吸入是纳米氧化锌进入人体并在肺部沉积的一条重要途径,肺部暴露于纳米氧化锌后将引发一系列毒效应。纳米氧化锌导致肺毒性的机制与Zn^(2+)释放、氧化应激、DNA损伤、自噬、炎症和肺表面活性物质功能异常等有关。本文综述了纳米氧化锌的肺毒性作用及机制,并总结防治策略,可为安全使用纳米材料提供科学依据,也为防治纳米毒性提供潜在干预策略。Zinc oxide nanoparticles(ZnO NPs)have been gradually introduced into people′s lives due to their excellent properties.In daily contact,ZnO NPs can enter the human body in a variety of ways and accumulate in tissues and organs.Inhalation is an important means by which ZnO NPs enter the human body and deposit in lungs.Studies have shown that exposure of lungs to ZnO NPs will cause a range of negative effects.The mechanism of pulmonary toxicity induced by ZnO NPs is related to Zn^(2+)release,oxidative stress,DNA damage,autophagy,inflammation and pulmonary surfactant dysfunction.This paper reviews the pulmonary toxicity and mechanisms of ZnO NPs,and summarizes the prevention and treatment strategies,which provides scientific basis for safer use of nanomaterials,and potential intervention strategies for the prevention and treatment of nanotoxicity.

关 键 词：纳米氧化锌 肺毒性 呼吸暴露 毒性机制 

分 类 号：R992[医药卫生—毒理学]