绝经后女性骨质疏松症的危险因素分析及其与刚地弓形虫感染的相关性  

An Analysis of Risk Factors for Osteoporosis in Postmenopausal Women and Its Correlation with Toxoplasma Gondii Infection

作　　者：程国伟 夏进军 刘庆阳 邬黎菁 周智毅 王秋波 CHENG Guowei;XIA Jinjun;LIU Qingyiang;WU Lijing;ZHOU Zhiyi;WANG Qiubo(Department of Laboratory Medicine,Wuxi No.9 People’s Hospital,Wuxi 214061,China;Radiology,Wuxi No.9 People’s Hospital,Wuxi 214061,China;Orthopedics,Wuxi No.9 Hospital Affiliated toSoochow University,Wuxi No.9 People’s Hospital,Wuxi 214061,China)

机构地区：[1]江苏省无锡市第九人民医院检验科,江苏无锡214061 [2]江苏省无锡市第九人民医院放射科,江苏无锡214061 [3]江苏省无锡市第九人民医院骨科,江苏无锡214061

出　　处：《标记免疫分析与临床》2024年第10期1847-1850,1860,共5页Labeled Immunoassays and Clinical Medicine

基　　金：江苏省卫生健康委医学科研立项面上项目(编号:H2023093);无锡市卫生健康委中青年拔尖人才资助计划(编号:BJ2023109)。

摘　　要：目的探讨绝经后女性骨质疏松症的危险因素及其与刚地弓形虫感染的相关性。方法选择2019年1月至2022年6月我院收治的骨密度异常的绝经妇女569例,回顾性分析所有患者的临床资料,均采用双能X线吸收检测法对骨密度进行测定,分为骨量减少组263例,骨质疏松症组306例。对绝经后女性骨质疏松症的危险因素进行单因素、多因素Logistic回归分析;并采用酶联免疫吸附法测定患者血清中抗弓形虫IgG抗体水平,分析绝经后女性骨质疏松症与刚地弓形虫阳性的相关性。结果569例患者中共检出血清抗刚地弓形虫IgG抗体水平阳性92例,占16.17%(92/569),其中骨量减少组18例、骨质疏松症组74例。经单因素分析,骨量减少组年龄分布普遍小于骨质疏松症组;骨量减少组产次分布普遍低于骨质疏松症组;骨量减少组绝经时间6~10年者人数少于骨质疏松症组;骨量减少组规律运动人数高于骨质疏松症组,差异均有统计学意义(P<0.05)。经多因素Logistic回归分析,年龄大、绝经时间长、无规律运动是造成绝经后女性骨质疏松症的主要危险因素(P<0.05)。经Spearman相关性分析,绝经后女性骨质疏松症与刚地弓形虫阳性呈明显正相关(P<0.05)。结论年龄大、绝经时间长、无规律运动是造成绝经后女性骨质疏松症的主要危险因素,临床应加强刚地弓形虫感染防控并采取积极应对措施,减少绝经后女性骨质疏松发生。Objective To explore risk factors of osteoporosis in postmenopausal women and their correlations with Toxoplasma gondii infection.Methods 569 postmenopausal women with abnormal bone density admitted to our hospital from January,2019 to June,2022 were selected for the study.Clinical data of all patients were retrospectively analyzed,and bone density was measured using dual energy X-ray absorption detection method.263 cases of bone loss were included in the bone loss group,while 306 cases of osteoporosis were included in the osteoporosis group.We conducted univariate and multivariate logistic regression analysis to identify potential risk factors of osteoporosis in postmenopausal women;Enzyme-linked immunosorbent assay was used to determine level of anti-Toxoplasma gondii IgG antibodies in patient’s serum,and to further analyze the correlation between postmenopausal female osteoporosis and Toxoplasma gondii infection.Results Out of 569 patients,92(16.17%)were found to have positive levels of serum anti-Toxoplasma gondii IgG antibodies,including 18 cases in the bone loss group and 74 cases in the osteoporosis group.According to univariate analysis,the age distribution of the group with reduced bone mass was generally smaller than that of the group with osteoporosis;The distribution of parity in the group with reduced bone mass was generally lower than that in the group with osteoporosis;The number of postmenopausal women with 6-10 years of bone loss group was less than that of osteoporosis group;The number of regular exercise participants in the bone loss group was significantly higher than that in the osteoporosis group(P<0.05).According to multiple logistic regression analysis,age,prolonged menopause,and irregular exercise were all main risk factors for osteoporosis in postmenopausal women(P<0.05).According to Spearman correlation analysis,osteoporosis in postmenopausal women was significantly positively correlated with positive results of Toxoplasma gondii(P<0.05).Conclusion Aging,prolonged menopause,and irregu

关 键 词：绝经 骨质疏松症 危险因素 刚地弓形虫 

分 类 号：R711[医药卫生—妇产科学]