鼻咽部冲洗联合抗感染治疗在反复呼吸道感染患儿中的应用价值  

Application value of nasopharyngeal irrigation combined with anti-infection therapy on children with recurrent respiratory tract infection

作　　者：王妍 朱彬晖 WANG Yan;ZHU Bin-hui(Department of Pediatrics,the First Affiliated Hospital of Air Force Military Medical University,Xi an 710032,Shaanxi,China)

机构地区：[1]空军军医大学第一附属医院儿科,陕西西安710032

出　　处：《川北医学院学报》2024年第11期1486-1489,共4页Journal of North Sichuan Medical College

基　　金：国家自然科学基金(8230020877)。

摘　　要：目的:探究鼻咽部冲洗联合抗感染治疗对反复呼吸道感染(RRTI)的患儿血象及短期再感染率的影响。方法:选取98例RRTI患儿为研究对象,根据治疗方式不同分为对照组和观察组,每组患儿各49例。对照组予以常规抗感染治疗;观察组予以常规抗感染治疗联合鼻咽部冲洗,均连续治疗5 d。比较两组患儿症状体征缓解时间、炎症指标[肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)、γ干扰素(IFN-γ)、白细胞介素12p70(IL-12p70)]、血象及抗生素使用率;随访3个月,统计短期再感染率。结果:与对照组相比,观察组患儿鼻塞、流涕、咳嗽、咳痰、气促各症状及发热、咽部红肿、扁桃体肿大、淋巴肿大、肺啰音各体征缓解时间更短(P<0.05)。治疗后5 d,与对照组相比,观察组患儿外周血TNF-α、IL-8、IFN-γ、IL-12p70及白细胞计数、单核细胞计数均更低(P<0.05);观察组患儿抗生素使用率、短期再感染率更低(36.73%vs.65.31%;4.08%vs.18.37%,P<0.05)。结论:鼻咽部冲洗联合抗感染治疗学龄前儿童RRTI,可促进症状体征缓解及炎症、血象恢复,降低抗生素使用率及短期再感染率。Objective:To explore the influence of nasopharyngeal irrigation combined with anti-infection therapy on hemogram and short-term reinfection rate in children with recurrent respiratory tract infection(RRTI).Methods:98 children with RRTI were selected as the research subjects,and were classified into control group and observation group according to the different treatment methods.Control group was given conventional anti-infection therapy,whereas observation group received conventional anti-infection therapy combined with nasopharyngeal irrigation.49 children in each group received continuous treatment for 5 days.The relief times of symptoms and signs,inflammatory indicators[tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),interferon-γ(IFN-γ),interleukin-12p70(IL-12p70)],hemogram and antibiotic use rate were compared between the two groups.After 3 months of follow-up,the short-term reinfection rate was counted.Results:Compared with control group,the relief times of symptoms of nasal congestion,runny nose,cough,expectoration and shortness of breath and signs of fever,throat swelling,tonsil enlargement,lymphatic enlargement and lung rales were shorter in observation group(P<0.05).At 5 d after treatment,the levels of peripheral blood TNF-α,IL-8,IFN-γand IL-12p70 and counts of peripheral blood white blood cell and monocyte of children in observation group were significantly lower(P<0.05).The observation group had lower antibiotic use rate and short-term reinfection rate(36.73%vs.65.31%,4.08%vs.18.37%,P<0.05).Conclusion:Nasopharyngeal irrigation combined with anti-infection therapy for preschool children with RRTI can promote the reliefs of symptoms and signs,recovery of inflammation and hemogram,and reduce the antibiotic use rate and short-term reinfection rate.

关 键 词：反复呼吸道感染 小儿 鼻咽部冲洗 血象 炎症指标 再感染率 

分 类 号：R729[医药卫生—儿科]