复方胰酶散联合益生菌治疗小儿腹泻的临床价值  

Clinical value of compound pancreatin powder combined with probiotics in treating infantile diarrhea

作　　者：康丽敏[1] 杜丽芳 范三丽[1] 白静洁 胡海燕[1] KANG Li-min;DU Li-fang;FAN San-li;BAI Jing-jie;HU Hai-yan(Department of Gastroenterology,Shanxi Children s Hospital,Taiyuan 030000,Shanxi,China)

机构地区：[1]山西省儿童医院消化科,山西太原030000

出　　处：《川北医学院学报》2024年第11期1528-1532,共5页Journal of North Sichuan Medical College

基　　金：中国妇幼保健协会-华润三九中医中西医结合妇幼健康专项研究基金(ZXY2020B07)。

摘　　要：目的:探究复方胰酶散联合益生菌治疗小儿腹泻的临床价值。方法:将122例腹泻患儿按干预方式不同分为联合组(n=61)和益生菌组(n=61)。联合组采用复方胰酶散联合益生菌治疗;益生菌组仅采用益生菌治疗。两组疗程均为15 d。比较两组患儿疗效、症状消退时间,血清核周型抗中性粒细胞抗体(p-ANCA)、血清淀粉样蛋白A(SAA)及白细胞介素6(IL-6),粪便肠道菌群相关指标[粪便钙卫蛋白(FC)水平、乳酸菌、双歧杆菌和大肠杆菌的数量]及不良反应发生情况。结果:联合组疗效比益生菌组更佳(P<0.05)。治疗后,联合组腹痛、呕吐、粪质稀薄消失时间和大便次数减少时间均短于益生菌组(P<0.05);联合组血清p-ANCA、SAA和IL-6水平均低于益生菌组(P<0.05);FC含量低于益生菌组(P<0.05),粪便乳酸杆菌和双歧杆菌数量多于益生菌组(P<0.05),大肠杆菌数量少于益生菌组(P<0.05)。联合组和益生菌组不良反应比较,差异无统计学意义(P>0.05)。结论:复方胰酶散联合益生菌治疗小儿腹泻病疗效明显,能有效缩短症状消退时间,改善血清炎症水平,有利于纠正肠道菌群失调。Objective:To explore the clinical value of compound pancreatin powder combined with probiotics in the treatment of infantile diarrhea.Methods:122 children with diarrhea were divided into combined group(n=61)and probiotics group(n=61)by different intervention methods.The combined group was treated with compound pancreatin powder combined with probiotics,while the probiotics group was only given probiotics.Both groups were treated for 15 days.The efficacy,symptom regression time,serum perinuclear anti-neutrophil antibody(p-ANCA),serum amyloid A(SAA)and interleukin 6(IL-6),fecal intestinal flora related indicators[fecal calprotectin(FC),Lactobacillus,Bifidobacterium,Escherichia coli]and adverse reactions were compared between the two groups.Results:The efficacy in combined group was better than that in probiotics group(P<0.05).The abdominal pain disappearance time,vomiting disappearance time,fecal thinning disappearance time and stool frequency reduction time in combined group were shorter compared to probiotics group(P<0.05).After treatment,the levels of serum p-ANCA,SAA and IL-6 were lower in combined group than those in probiotics group(P<0.05).The FC content was lower than that in probiotics group(P<0.05),and the fecal Lactobacillus count and Bifidobacterium count were more(P<0.05),while the Escherichia coli count was less compared to probiotics group(P<0.05).There was no statistical difference in the occurrence of adverse reactions between combined group and probiotics group(P>0.05).Conclusion:Compound pancreatin powder combined with probiotics has significant efficacy in the treatment of infantile diarrhea.It can effectively shorten the symptom regression time,improve the serum inflammation level,and help to correct the imbalance of intestinal flora.

关 键 词：小儿腹泻病 复方胰酶散 益生菌 血清淀粉样蛋白A 白细胞介素6 

分 类 号：R725.7[医药卫生—儿科]