抗菌药物专项整治活动前后医院抗菌药物使用和细菌耐药性变化分析  

Analysis of changes in antimicrobial drug use and bacterial resistance in hospitals before and after special antimicrobial drug regulation activities

作　　者：叶蓉 蒯婧婧 YE Rong;KUAI Jing-jing(Department of Pharmacy,Yancheng Clinical College of Nanjing Medical University,Yancheng Third People's Hospital,Yancheng 224000,Jiangsu,China;Department of Infection Control,Yancheng Clinical College of Nanjing Medical University,Yancheng Third People's Hospital,Yancheng 224000,Jiangsu,China)

机构地区：[1]盐城市第三人民医院•南京医科大学盐城临床医学院药学部,江苏盐城224000 [2]盐城市第三人民医院•南京医科大学盐城临床医学院感控处,江苏盐城224000

出　　处：《川北医学院学报》2024年第11期1563-1566,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨抗菌药物专项整治活动前后医院抗菌药物使用和细菌耐药性的变化。方法:整理盐城市第三人民医院2021年(专项整治前)至2022年(专项整治后)抗菌药物临床使用情况的相关数据,统计抗菌药物的使用情况、重点药物联用前的病原学送检情况及细菌耐药情况。结果:专项整治活动后,住院患者抗菌药物的使用率下降(P<0.05),重点药物联用前病原学送检率明显提升(P<0.05)。多重耐药菌主要为肠杆菌、革兰阴性菌、金黄色葡萄球菌,整治后细菌耐药性问题有所改善(P<0.05)。结论:专项整治计划实施后,医院对抗菌药物尤其是重点药物的使用更加合理,重点药物联用前未送检以及细菌耐药性问题均有不同程度改善。Objective:To investigate the changes of antimicrobial drug use and bacterial resistance in hospitals before and after the special antimicrobial drug regulation activities.Methods:To collate data on the clinical use of antimicrobial drugs in our hospital from 2021(before the special rectification)to 2022(after the special rectification),and to count the use of antimicrobial drugs,the delivery of key drugs for testing before co-administration and the drug resistance situation.Results:After the special rectification activities,the use of antimicrobial drugs in inpatients decreased and the rate of pre-submission testing of key drugs increased significantly(P<0.05).The multi-drug resistant bacteria were mainly Enterobacteriaceae,Gram-negative bacteria and Staphylococcus aureus,and the drug resistance problem improved after the remediation(P<0.05).Conclusion:After the implementation of the special remediation programme,the use of antimicrobial drugs,especially priority drugs,is more rational in hospitals,and the problem of non-delivery of priority drugs before co-administration and bacterial resistance improved to varying degrees.

关 键 词：抗菌药物 细菌耐药性 病原学送检 送检率 

分 类 号：R453.2[医药卫生—治疗学] R969[医药卫生—临床医学]