黄精降压汤治疗气虚型高血压合并失眠患者的临床研究  

Clinical Study on Huangjing Jiangya Decoction in the Treatment of Patients with Hypertension of Qi-Deficiency Type Accompanied by Insomnia

作　　者：史雯[1] 马海娟[1] 何晋涛[1] 董蕾[1] 刘瑶[1] 赵会灵 邢远 SHI Wen;MA Haijuan;HE Jintao;DONG Lei;LIU Yao;ZHAO Huiling;XING Yuan(Traditional Chinese Medicine Department of Beijing Sixth Hospital,Beijing 100007,China;School of Public Health,Xi’an Medical University,Xi’an 710021,China)

机构地区：[1]北京市第六医院中医科,北京100007 [2]西安医学院公共卫生学院,陕西西安710021

出　　处：《南京中医药大学学报》2024年第11期1256-1262,共7页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：首都卫生发展科研专项(首发2022-2-7013);北京市东城区优秀人才培养资助项目(2022-dchrcpyzz-60)。

摘　　要：目的观察黄精降压汤对气虚型高血压合并失眠患者血压和睡眠情况的影响。方法选择符合纳入标准的气虚型高血压合并失眠患者73例,随机分为观察组36例、对照组37例。对照组予苯磺酸氨氯地平片治疗,观察组在对照组基础上予黄精降压汤口服,2组均连续治疗8周。观察2组患者治疗前后中医症候积分、诊室血压(OBPM)、家庭血压(HBPM)、24 h动态血压(ABPM)、匹兹堡睡眠指数(PSQI)评分变化情况及临床疗效。结果治疗后,观察组中医证候积分明显下降(P<0.05,P<0.01),优于对照组(P<0.01);2组OBPM、HBMP均显著下降(P<0.05,P<0.01),观察组优于对照组(P<0.05,P<0.01);观察组ABPM明显降低(P<0.01),优于对照组(P<0.05,P<0.01);观察组睡眠质量、入睡时间、睡眠时间、日间功能障碍评分以及PSQI总分均明显降低(P<0.01),优于对照组(P<0.05,P<0.01);观察组高血压、失眠的临床疗效均优于对照组(P<0.01)。结论黄精降压汤联合氨氯地平可改善气虚型高血压合并失眠患者的症状,降低血压,提高睡眠质量,缩短入睡时间,缓解日间功能障碍,具有较好的临床疗效。OBJECTIVE To observe the effect of Huangjing Jiangya Decoction on blood pressure and sleep in patients with hypertension of qi-deficiency type accompanied by insomnia.METHODS 73 patients with hypertension of qi-deficiency type accompanied by insomnia who met the inclusion criteria were selected and randomly divided into an observation group of 36 cases and a control group of 37 cases.The control group was treated with amlodipine besylate tablets,and the observation group was given Huangjing Jiangya Decoction oral treatment on the basis of the control group.Both groups were treated continuously for 8 weeks.The changes in TCM syndrome scores,office blood pressure monitoring(OBPM),home blood pressure monitoring(HBPM),24-hour ambulatory blood pressure monitoring(ABPM),Pittsburgh Sleep Quality Index(PSQI)scores and clinical efficacy of the two groups of patients before and after treatment were observed.RESULTS After treatment,the TCM syndrome scores in the observation group were significantly decreased(P<0.05,P<0.01),which were better than the control group(P<0.01);OBPM and HBMP in both groups were significantly reduced(P<0.05,P<0.01),the observation group was better than the control group(P<0.05,P<0.01);the ABPM of the observation group was significantly reduced(P<0.01),which was better than the control group(P<0.05,P<0.01);the sleep quality,sleep latency,sleep duration,daytime dysfunction score and PSQI total score of the observation group were significantly decreased(P<0.01),which were better than those in the control group(P<0.05,P<0.01);the clinical efficacy of hypertension and insomnia in the observation group was both better than the control group(P<0.01).CONCLUSION Huangjing Jiangya Decoction combined with amlodipine can improve the symptoms of patients with hypertension of qi-deficiency type accompanied by insomnia,lower blood pressure,improve sleep quality,shorten sleep latency,alleviate daytime dysfunction,and has good clinical efficacy.

关 键 词：高血压 失眠 气虚型 黄精降压汤 临床疗效 

分 类 号：R259.441[医药卫生—中西医结合]