Bleeding characteristics and mortality outcomes following ST-elevation myocardial infarction thrombolysis:a 5-year analysis in an Asian population  

作　　者：Hock Peng Koh Jivanraj RNagarajah Hasnita Hassan Noel Thomas Ross 

机构地区：[1]Pharmacy Department,Hospital Kuala Lumpur,Ministry of Health Malaysia,Kuala Lumpur 50586,Malaysia [2]Emergency and Trauma Department,Hospital Kuala Lumpur,Ministry of Health Malaysia,Kuala Lumpur 50586,Malaysia [3]Medical Department,Hospital Kuala Lumpur,Ministry of Health Malaysia,Kuala Lumpur 50586,Malaysia

出　　处：《World Journal of Emergency Medicine》2024年第6期433-440,共8页世界急诊医学杂志（英文）

摘　　要：BACKGROUND:Bleeding outcomes are crucial primary safety endpoints in studies involving thrombolytic agents.This study aimed to determine the incidence,characteristics and mortality outcomes of bleeding following ST-elevation myocardial infarction(STEMI)thrombolysis in an Asian population.METHODS:This single-centre retrospective study included all STEMI patients who received thrombolytic therapy from 2016 to 2020 in a Malaysian tertiary hospital.Total population sampling was used in this study.The primary outcome was bleeding events post-thrombolysis,categorised using the Thrombolysis in Myocardial Infarction(TIMI)bleeding criteria.Inferential statistics were used to determine the associations between relevant variables.RESULTS:Data from 941 patients were analysed.A total of 156(16.6%)STEMI patients bled post-thrombolysis.Major,minor,and minimal TIMI occurred in 7(0.7%),17(1.8%),and 132(14.0%)patients,respectively.Age 65 years(P=0.031)and Malaysian Chinese(P=0.008)were associated with a higher incidence of bleeding post-thrombolysis.Conversely,foreigners(P=0.032)and current smoker(P=0.007)were associated with a lower incidence of bleeding.Both TIMI major(P<0.001)and TIMI minor(P<0.001)were associated with a higher incidence of all-cause in-hospital mortality among STEMI patients.TIMI minor bleeding was significantly higher in the streptokinase recipients.The bleeding sites were comparable between streptokinase and tenecteplase recipients,except for a significantly higher incidence of gastrointestinal bleeding in the streptokinase recipients(P=0.027).CONCLUSION:In our Asian population,the incidence of total bleeding events following STEMI thrombolysis is comparable to that previously reported.The development of TIMI major and minor bleeding complications is associated with higher mortality.

关 键 词：BLEEDING ST-elevation myocardial infarction thrombolysis ASIAN TENECTEPLASE STREPTOKINASE 

分 类 号：R542.22[医药卫生—心血管疾病]