Association of alcohol consumption with aortic aneurysm and dissection risk:results from the UK Biobank cohort study  

作　　者：Yaowen Liang Guoxiang Zou Dingchen Wang Weiyue Zeng Jiarui Zhang Xiaoran Huang Miao Lin Cong Mai Fei'er Song Yuelin Zhang Jinxiu Meng Hongliang Feng Yu Huang Xin Li 

机构地区：[1]Department of Emergency Medicine,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China [2]Shantou University Medical College,Shantou 515063,China [3]South China University of Technology,Guangzhou 510080,China [4]Medical Big Data Center,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China [5]Department of Critical Care Medicine,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China [6]Center for Sleep and Circadian Medicine,the Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510080,China [7]Department of Ophthalmology,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China

出　　处：《World Journal of Emergency Medicine》2024年第6期465-474,共10页世界急诊医学杂志（英文）

基　　金：supported by grants from the Ministry of Science and Technology of the People’s Republic of China,(No.2020AAA0109605 to XL);grants from the National Natural Science Foundation of China(No.82272246 and 82072225 to XL);Science and Technology Program of Guangzhou,China(No.202206010044 to XL);High-level Hospital Construction Project of Guangdong Provincial People’s Hospital(No.DFJHBF202104 to XL).

摘　　要：BACKGROUND:Previous studies have reported inconsistent results with positive,negative,and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection(AAD).This study aimed to examine the connections between weekly alcohol consumption and the subsequent risk of AAD.METHODS:The UK Biobank study is a population-based cohort study.Weekly alcohol consumption was assessed using self-reported questionnaires and the congenital risk of alcohol consumption was also evaluated using genetic risk score(GRS).Cox proportional hazards models were used to estimate hazard ratios(HRs)with 95% confidence intervals(CIs)for the associations between alcohol consumption and AAD.Several sensitivity analyses were performed to assess the robustness of the results.RESULTS:Among the 388,955 participants(mean age:57.1 years,47.4% male),2,895 incident AAD cases were documented during a median follow-up of 12.5 years.Compared with never-drinkers,moderate drinkers(adjusted HR:0.797,95%CI:0.646-0.984,P<0.05)and moderate-heavy drinkers(adjusted HR:0.794,95%CI:0.635-0.992,P<0.05)were significantly associated with a decreased risk of incident AAD.Interaction-based subgroup analysis revealed that the protective effect of moderate drinking was reflected mainly in participants younger than 65 years and women.CONCLUSION:Our findings support a protective effect of moderate alcohol consumption on AAD,but are limited to participants younger than 65 years and women.

关 键 词：Alcohol consumption Aortic aneurysm and dissection Genetic risk score Cohort study UK Biobank 

分 类 号：R543.1[医药卫生—心血管疾病]