5-氨基酮戊酸光动力疗法联合人干扰素α-2β治疗尖锐湿疣的效果分析  

Efficacy of 5-Aminolaevulinic acid photodynamic therapy combined with human interferonα-2βin the treatment of condyloma acuminatum

作　　者：方宇辉 王馨依 李坤鹏 王伟 FANG Yuhui;WANG Xinyi;LI Kunpeng;WANG Wei(Department of Dermatology,Fuyang People′s Hospital of Anhui Province,Fuyang,Anhui,236000)

机构地区：[1]安徽省阜阳市人民医院皮肤科,安徽阜阳236000

出　　处：《实用临床医药杂志》2024年第20期27-31,共5页Journal of Clinical Medicine in Practice

基　　金：安徽省重点研发计划项目(2022SF-0162)。

摘　　要：目的探讨5-氨基酮戊酸光动力疗法(ALA-PDT)联合人干扰素α-2β治疗尖锐湿疣(CA)的效果及对血清T细胞亚群和趋化因子配体19(CCL19)、基质金属蛋白酶-3(MMP-3)水平的影响。方法选择86例CA患者为研究对象,根据随机数字表法将CA患者分为对照组(ALA-PDT治疗)和观察组(ALA-PDT联合人干扰素α-2β治疗),每组43例。比较2组患者临床疗效以及治疗前后血清T细胞亚群、CCL19、MMP-3水平变化情况,并记录治疗期间不良反应发生情况。随访6个月,记录复发疣体数量和复发率。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)较对照组升高,差异有统计学意义(P<0.05)。与对照组比较,观察组治疗后血清CCL19升高,MMP-3下降,差异有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。对照组复发率、平均复发疣体数量高于观察组,差异有统计学意义(P<0.05)。结论ALA-PDT联合人干扰素α-2β治疗尖锐湿疣效果显著,可调节血清T细胞亚群水平,降低MMP-3水平,提升CCL19水平,且安全性较好。Objective To investigate the therapeutic effects of 5-Aminolaevulinic acid photodynamic therapy(ALA-PDT)combined with human interferonα-2βin the treatment of condyloma acuminatum(CA)and its impacts on serum T-cell subsets,chemokine ligand 19(CCL19),and matrix metalloproteinase-3(MMP-3)levels.Methods A total of 86 patients with CA were enrolled and randomly divided to control group(treated with ALA-PDT alone)and observation group(treated with ALA-PDT combined with human interferonα-2β),with 43 patients in each group.Clinical efficacy,changes in serum T-cell subsets,CCL19,and MMP-3 levels before and after treatment were compared between the two groups.Adverse reactions during treatment were recorded.Patients were followed up for 6 months to record the number of warts and recurrence rate.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the levels of CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)in the observation group were significantly elevated compared to the control group(P<0.05).Additionally,serum CCL19 levels increased,while MMP-3 levels decreased in the observation group post-treatment compared to the control group(P<0.05).No significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate and the number of average recurrent warts were significantly higher in the control group than in the observation group(P<0.05).Conclusion The combination of ALA-PDT and human interferonα-2βexhibits remarkable efficacy in the treatment of CA,which can effectively regulate serum T-cell subset levels,reduce MMP-3 levels,enhance CCL19 levels,and demonstrates good safety.

关 键 词：5-氨基酮戊酸光动力疗法 人干扰素α-2β 尖锐湿疣 趋化因子配体19 基质金属蛋白酶-3 

分 类 号：R751[医药卫生—皮肤病学与性病学] R759[医药卫生—临床医学] R446.6