2种不同飞秒激光术治疗薄角膜近视散光的效果分析  

Effects of two different femtosecond laser surgeries for the treatment of thin corneal myopic astigmatism

作　　者：周传海 王丽君 何元旭[1] 覃冬[1] ZHOU Chuanhai;WANG Lijun;HE Yuanxu;QIN Dong(Department of Ophthalmology,the Third People′s Hospital of Chengdu of Sichuan Province,Chengdu,Sichuan 610000)

机构地区：[1]四川省成都市第三人民医院眼科,四川成都610000

出　　处：《实用临床医药杂志》2024年第20期48-54,共7页Journal of Clinical Medicine in Practice

基　　金：四川省自然科学基金项目(2022NSFSC1331)。

摘　　要：目的探讨飞秒激光制瓣的准分子激光原位角膜磨镶术(FS-LASIK)与飞秒激光小切口角膜基质透镜取出术(SMILE)治疗薄角膜近视散光的效果。方法选取2022年9月—2023年9月本院收治的薄角膜近视散光患者128例为研究对象,随机分为FS-LASIK组(64例,128眼,接受FS-LASIK治疗)和SMILE组(64例,124眼,接受SMILE治疗)。比较2组患者术前及术后1年视力水平[未矫正视力(UCVA)、最佳矫正视力(BCVA)],术后3、6、12个月的屈光参数等效球镜(SE)水平,术前及术后1年角膜表面形态[角膜平均曲率值(K_(Ave))、角膜表面规则指数(SRI)、角膜表面不对称指数(SAI)],以及角膜生物力学参数[角膜扩张综合偏差分析指数(BAD-D)、角膜生物力学指数(CBI)、综合分析指数(TBI)]、角膜损伤程度[角膜内皮细胞计数、角膜内皮细胞大小变异系数(CV)]、术后散光矫正矢量指标[误差幅度(ME)、误差角度(AE)、矫正指数(CI)和成功指数(IOS)]的差异,并记录术后残余基质床厚度及并发症发生情况。结果术后1年,2组UCVA和BCVA均较术前升高,差异有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05)。术后3、6、12个月,2组SE水平均高于术前,差异有统计学意义(P<0.05),但组间以上时点的SE水平比较,差异无统计学意义(P>0.05)。术后1年,2组角膜表面形态KAve、SRI、SAI水平均较术前降低,且SMILE组低于FS-LASIK组,差异有统计学意义(P<0.05)。术后1年,2组BAD-D和TBI均较术前升高,CBI均较术前降低,但SMILE组BAD-D和TBI低于FS-LASIK组,CBI高于FS-LASIK组,差异有统计学意义(P<0.05)。术后1年,2组角膜内皮细胞计数均较术前降低,角膜内皮细胞大小CV较术前升高,但SMILE组角膜内皮细胞计数高于FS-LASIK组,角膜内皮细胞大小CV低于FS-LASIK组,差异有统计学意义(P<0.05)。2组术后ME、AE、CI和IOS比较,差异无统计学意义(P>0.05)。术后FS-LASIK组残余基质床厚度为(302.01±55.03)μm,SMILE组为(Objective To explore the effect of femtosecond laser-assisted in situ keratomileusis(FS-LASIK)and small incision lenticule extraction(SMILE)femtosecond laser in the treatment of myopic astigmatism with thin cornea.Methods From September 2022 to September 2023,128 patients with thin cornea myopic astigmatism in the hospital were selected and randomly divided into FS-LASIK group(64 cases,128 eyes,receiving FS-LASIK)and SMILE group(64 cases,124 eyes,receiving SMILE).The visual acuity[uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA)]before surgery and at 1 year after surgery,refractive parameter spherical equivalent(SE)at 3,6 and 12 months after surgery,corneal surface morphology[average corneal curvature(K_(Ave)),surface regularity index(SRI),surface asymmetry index(SAI)]before surgery and at 1 year after surgery,corneal biomechanic indicators[corneal expansion comprehensive deviation analysis index(BAD-D),corneal biomechanical index(CBI),total biomechanical index(TBI)]and corneal injury degree[corneal endothelial cell count,corneal endothelial cell size,coefficient of variation(CV)]and differences in postoperative astigmatism correction vector indicators[magnitude of error(ME),angle of error(AE),correction index(CI),and index of success(IOS)]were compared.Residual stromal bed thickness and the incidence of complications after surgery were recorded.Results One year after surgery,both UCVA and BCVA in both groups were improved compared with preoperation(P<0.05),but there were no significant between-group differences(P>0.05).At 3,6,and 12 months postoperatively,the SE levels in both groups were higher than preoperation(P<0.05);however,there were no statistically significant differences in SE levels between the groups at above time points(P>0.05).One year after surgery,K Ave,SRI,and SAI in both groups were lower than preoperative levels,and the SMILE group was lower than those in the FS-LASIK group(P<0.05).One year after operation,BAD-D and TBI in both groups were higher than preoperative levels,while

关 键 词：飞秒激光辅助的原位角膜磨镶术 小切口微透镜提取术 薄角膜 近视 散光 视力水平 

分 类 号：R61[医药卫生—外科学] R778.1[医药卫生—临床医学] R772.2