妇科宫腔镜电切术全凭静脉麻醉中应用瑞马唑仑与丙泊酚诱导及维持的临床效果  

Clinical Effects of Induction and Maintenance of Remidazolam and Propofol in Total Intravenous Anesthesia for Gynecological Hysteroscopic Resection

作　　者：郎秀伟 LANG Xiu-Wei(Anesthesiology Department of Tai'an Maternal and Child Health Hospital,Tai'an 271000,China)

机构地区：[1]泰安市妇幼保健院麻醉科,山东泰安271000

出　　处：《中国药物经济学》2024年第10期56-59,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨妇科宫腔镜电切术全凭静脉麻醉中应用瑞马唑仑、丙泊酚诱导及维持的临床效果。方法选取2022年11月至2023年8月泰安市妇幼保健院收治的行妇科宫腔镜电切术患者60例为研究对象,采用随机数字表法分为对照组(n=30)和观察组(n=30)。对照组患者全凭静脉麻醉中应用丙泊酚诱导及维持,观察组患者全凭静脉麻醉中应用瑞马唑仑诱导及维持。比较两组患者麻醉效果、血流动力学指标[心率(HR)、呼吸(RR)、血氧饱和度(SPO_(2))、平均动脉压(MAP)]、术后镇静效果(Ramsay评分)、疼痛程度[视觉模拟评分法(VAS)评分]、不良反应。结果两组手术时间比较差异无统计学意义(P>0.05),观察组麻醉诱导起效、术后苏醒、术后定向力恢复时间短于对照组(P<0.05);观察组麻醉诱导5 min(T_(2))~术后清醒时(T_(5))时刻HR、RR、SPO_(2)、MAP高于对照组(P<0.05);观察组术后30 min Ramsay评分高于对照组,术后6 h的VAS评分低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论相比于丙泊酚,妇科宫腔镜电切术全凭静脉麻醉诱导及维持中应用瑞马唑仑的麻醉效果更好,患者血流动力学更平稳,术后镇静镇痛效果更好。Objective To explore the clinical effects of induction and maintenance of remidazolam and propofol in total intravenous anesthesia for gynecological hysteroscopic resection.Methods Sixty patients who underwent gynecological hysteroscopic electroresection treated in Tai'an Maternal and Child Health Hospital from November 2022 to August 2023 were selected as the study objects,and were divided into control group(n=30)and observation group(n=30)by random number table method.Patients in control group were induced and maintained by intravenous anesthesia with propofol,and patients in observation group were induced and maintained by intravenous anesthesia with remazolam.Anesthesia effect,hemodynamic indexes(heart rate(HR),respiration(RR),blood oxygen saturation(SPO_(2)),mean arterial pressure(MAP)),postoperative sedation effect(Ramsay score),pain degree(VAS score)and adverse reactions were compared between the two groups.Results There was no significant difference in operation time between the two groups(P>0.05).The time of anesthesia induction,recovery and orientation recovery in the observation group was shorter than that in the control group(P<0.05).HR,RR,SPO 2 and MAP in observation group were higher than those in control group from 5 min(T_(2))to after anesthesia induction(T_(5))(P<0.05).The Ramsay score 30 min after operation in the observation group was higher than that in the control group,and the VAS score 6 h after operation was lower than that in the control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared to propofol,the use of remidazolam in the induction and maintenance of total intravenous anesthesia for gynecological hysteroscopic resection has better anesthesia effects,smoother patient hemodynamics,and better postoperative sedative and analgesic effects.

关 键 词：妇科宫腔镜电切术 全凭静脉麻醉 瑞马唑仑 丙泊酚 

分 类 号：R713.4[医药卫生—妇产科学] R971[医药卫生—临床医学]