强脉冲光联合氨甲环酸片对黄褐斑患者皮肤生理参数、面部症状及血清激素水平的影响  

Effects of Intense Pulsed Light Combined with Tranexamic Acid Tablets on Skin Physiological Parameters,Facial Symptoms and Serum Hormone Levels in Chloasma Patients

作　　者：朱洁 陆燕 吉津 徐萍 陈芳 郭琴 ZHU Jie;LU Yan;JI Jin;XU Ping;CHEN Fang;GUO Qin(Department of Dermatology,Nanjing University of Traditional ChineseMedicine Affiliated Hospital,Nanjing,Jiangsu,210029,China;Nanjing Jiangning Guze Medical Beauty Clinic,Nanjing,Jiangsu,210000,China)

机构地区：[1]南京中医药大学附属医院(江苏省中医院)皮肤科,江苏南京210029 [2]南京江宁顾泽医疗美容门诊,江苏南京210000

出　　处：《现代生物医学进展》2024年第19期3633-3637,3660,共6页Progress in Modern Biomedicine

基　　金：江苏省中医药科技发展计划项目(MS2021015)。

摘　　要：目的:观察黄褐斑患者经氨甲环酸片和强脉冲光联合治疗后,患者皮肤生理参数、面部症状及血清激素水平的变化情况。方法:按随机数字表法将我院2020年2月至2022年10月收治的128例黄褐斑患者分为对照组(强脉冲光治疗,n=64)和观察组(强脉冲光联合氨甲环酸片治疗,n=64),对比两组患者的面部症状评分、皮肤生理参数、血清激素水平和不良反应发生率。结果:两组治疗3个月后黄褐斑面积及严重程度评分(MASI)、皮损颜色评分、皮损面积评分下降,且观察组低于对照组(P<0.05)。两组治疗3个月后经皮水分丢失(TEWL)下降,且观察组低于对照组;表皮油脂含量、角质层含水量升高,且观察组高于对照组(P<0.05)。观察组治疗3个月后卵泡生成激素(FSH)、睾酮(T)、雌二醇(E_(2))、黄体生成激素(LH)下降,且观察组低于对照组(P<0.05)。两组不良反应发生率组间对比未见差异(P>0.05)。结论:黄褐斑患者在强脉冲光治疗基础上联合氨甲环酸片,面部症状改善效果更佳,同时可更好的调节皮肤生理参数及血清激素水平,未见明显的不良反应发生风险升高,具有较好的安全性。Objective:To observe the changes of skin physiological parameters,facial symptoms and serum hormone levels in chloasma patients after combine treatment with tranexamic acid tablets and intense pulsed light.Methods:According to the random number table method,128 chloasma patients admitted to our hospital from February 2020 to October 2022 were divided into control group(intense pulsed light treatment,n=64)and observation group(intense pulsed light combine with tranexamic acid tablets,n=64),the facial symptom scores,skin physiological parameters,serum hormone levels and incidence of adverse reactions were compared in two groups.Results:After 3 months of treatment,the area and severity score(MASI),lesion color score,and lesion area score of the two groups decreased,and the observation group was lower than the control group(P<0.05).After 3 months of treatment,transcutaneous water loss(TEWL)decreased in both groups,and the observation group was lower than the control group;The content of epidermal oil and water in the stratum corneum increased,and the observation group was higher than the control group(P<0.05).After 3 months of treatment,the levels of follicle stimulating hormone(FSH),testosterone(T),estradiol(E_(2)),and luteinizing hormone(LH)decreased in the observation group was lower than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Chloasma patients combined with tranexamic acid tablets on the basis of intense pulsed light treatment have better improvement of facial symptoms,and can better regulate skin physiological parameters and serum hormone levels,there is no obvious increase in the risk of adverse reactions,with good safety.

关 键 词：强脉冲光 氨甲环酸片 黄褐斑 面部症状 皮肤生理参数 激素 

分 类 号：R758.42[医药卫生—皮肤病学与性病学] Q68[医药卫生—临床医学]