调气通便方对功能性便秘的应用效果及肠道微生物群影响  

Effect of Tiaoqi Tongbian Formula on Functional Constipation and the Influence of Intestinal Microbiota

作　　者：陈昶洲[1] 李熠萌[1] 李莉[1] 丛军[1] 张雯[1] CHEN Chang-zhou;LI Yi-meng;LI Li;CONG Jun;ZHANG Wen(Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200021,China)

机构地区：[1]上海中医药大学附属曙光医院消化内科,上海200021

出　　处：《现代生物医学进展》2024年第19期3661-3663,共3页Progress in Modern Biomedicine

基　　金：上海市名老中医学术经验研究室建设项目--朱抗美名老中医学术经验研究工作室(SHGZS-202205)。

摘　　要：目的:探讨调气通便方对功能性便秘的应用效果及肠道微生物群影响。方法:选取我院2022.8到2024.2收治的80例功能性便秘患者,分为观察组(n=40)与对照组(n=40)。对照组采取常规西药治疗,观察组在对照组基础上增加调气通便方治疗,对比两组相关指标。结果:观察组总有效率较对照组高(P<0.05);治疗后,观察组大便干结症状及中医证候积分均低于对照组(P<0.05);观察组Wexner、BSFS评分均低于对照组(P<0.05);观察组周排便次数高于对照组(P<0.05);治疗后两组乳酸杆菌、双歧杆菌以及类杆菌升高,大肠杆菌及粪肠球菌降低,且观察组改善更为明显(P<0.05)。结论:对功能性便秘患者联合使用调气通便方可提升其临床疗效,改善便秘症状和大便性状,增加患者周排便次数,改善肠道菌群结构。Objective:To investigate the effect of tiaoqitongbei prescription on functional constipation and the effect of intestinal microflora.Methods:80 patients with functional constipation admitted to our hospital from 2022.8 to 2024.2 were divided into observation group(n=40)and control group(n=40).The control group was treated with conventional western medicine,and the observation group was treated with tiaoqitongqi decoction on the basis of the control group.The relevant indexes of the two groups were compared.Results:The total effective rate of observation group was higher than that of control group(P<0.05).After treatment,the scores of dry stool symptom and related TCM syndrome in observation group were lower than those in control group(P<0.05);Wexner and BSFS scores in observation group were lower than those in control group(P<0.05).The frequency of weekly defecation in observation group was higher than that in control group(P<0.05).After treatment,Lactobacillus,bifidobacterium and bacterioid increased in two groups,and Escherichia coli and Enterococcus faecalis decreased,and the improvement was more obvious in the observation group(P<0.05).Conclusion:The combination of tiaoqitongfengfang for functional constipation patients can improve the clinical efficacy,improve constipation symptoms and stool characteristics,increase the weekly frequency of defecation,and improve the intestinal flora structure.

关 键 词：调气通便方 功能性便秘 肠道微生物群 

分 类 号：R442.2[医药卫生—诊断学]