老年重症肺炎合并呼吸衰竭患者血清α1-AT、sIL-2R、Gal-3检测的临床意义分析  

Clinical Significance of Serumα1-AT,sIL-2R and Gal-3 Detection in Elderly Patients with Severe Pneumonia Combined with Respiratory Failure

作　　者：李寿 张蕾[2] 王永鑫 王俊[3] 任娜[3] LI Shou;ZHANG Lei;WANG Yong-xin;WANG Jun;REN Na(Second Department of Intensive Care Medicine,Qingdao Haici Hospital Affiliated to Qingdao University(Qingdao Traditional Chinese Medicine Hospital),Qingdao,Shandong,266033,China;Department of Emergency,Qingdao Haici Hospital Affiliated to Qingdao University(Qingdao Traditional Chinese Medicine Hospital),Qingdao,Shandong,266033,China;Second Ward of First Department of Respiratory and Critical Care,Qingdao Haici Hospital Affiliated to Qingdao University(Qingdao Traditional Chinese Medicine Hospital),Qingdao,Shandong,266033,China)

机构地区：[1]青岛大学附属青岛市海慈医院(青岛市中医医院)重症医学二科,山东青岛266033 [2]青岛大学附属青岛市海慈医院(青岛市中医医院)急诊科,山东青岛266033 [3]青岛大学附属青岛市海慈医院(青岛市中医医院)呼吸与危重症一科二病区,山东青岛266033

出　　处：《现代生物医学进展》2024年第19期3685-3688,共4页Progress in Modern Biomedicine

基　　金：山东省科研基金资助项目(2020L0111)。

摘　　要：目的:探讨老年重症肺炎(SP)合并呼吸衰竭(RF)患者血清α1-抗胰蛋白酶(α1-AT)、可溶性白细胞介素-2受体(sIL-2R)、半乳糖凝集素-3(Gal-3)的临床意义。方法:选取我院收治的老年SP合并RF患者200例分为低危组、中危组、高危组,根据30 d预后分为死亡组和存活组。检测血清α1-AT、sIL-2R、Gal-3水平。多因素Logistic回归分析老年SP合并RF患者死亡的因素。结果:低危组、中危组、高危组血清α1-AT、sIL-2R、Gal-3水平依次升高(P<0.05)。200例老年SP合并RF患者30 d死亡率为30.50%(61/200)。年龄增加、病情程度重度和α1-AT、sIL-2R、Gal-3升高为老年SP合并RF患者死亡的独立危险因素,氧合指数升高为独立保护因素(P<0.05)。结论:老年SP合并RF患者血清α1-AT、sIL-2R、Gal-3水平升高与病情加重和预后不良密切相关。Objective:To investigate the clinical significance of serumα1-antitrypsin(α1-AT),soluble interleukin-2 receptor(sIL-2R)and galectin-3(Gal-3)in elderly patients with severe pneumonia(SP)combine with respiratory failure(RF).Methods:200 elderly patients with SP combine with RF who were admitted to our hospital were selected,patients were divided into low risk group,medium risk group and high risk group,patients were divided into death group and survival group according to the 30 days prognosis.Serumα1-AT,sIL-2R and Gal-3 levels were detected.The factors of death in elderly patients with SP combine with RF were analyzed by multivariate Logistic regression.Results:Serumα1-AT,sIL-2R and Gal-3 levels in low risk group,middle risk group and high risk group increased in turn(P<0.05).The 30 day mortality rate of 200 elderly patients with SP combine with RF was 30.50%(61/200).The increase of age,severity of disease and the increase ofα1-AT,sIL-2R and Gal-3 were independent risk factors for death in elderly patients with SP combine with RF,and the increase of oxygenation index was an independent protective factor(P<0.05).Conclusion:The increase of serumα1-AT,sIL-2R and Gal-3 levels in elderly patients with SP combine with RF are closely relate to the aggravation of the disease and poor prognosis.

关 键 词：老年 重症肺炎 呼吸衰竭 Α1-AT SIL-2R GAL-3 

分 类 号：R563[医药卫生—呼吸系统]