双歧杆菌三联活菌治疗新生儿黄疸对患儿肠道菌群、胆红素水平的影响  

Effects of Bifidobacterium Triple Viable Bacteria on Intestinal Floras and Bilirubin in Neonatal Jaundice

作　　者：孔梦琰 陶宏梅 甘轶文 王会丹 潘洋洋 KONG Meng-yan;TAO Hong-mei;GAN Yi-wen;WANG Hui-dan;PAN Yang-yang(Department of Neonatology,The Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing,Jiangsu,211100,China;Department of Pediatrics,The Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing,Jiangsu,211100,China)

机构地区：[1]南京医科大学附属江宁医院新生儿科,江苏南京211100 [2]南京医科大学附属江宁医院儿科,江苏南京211100

出　　处：《现代生物医学进展》2024年第19期3711-3714,3750,共5页Progress in Modern Biomedicine

基　　金：南京医科大学附属江宁医院青年创新科研基金项目(JNYYZXKY202119)。

摘　　要：目的:探讨双歧杆菌三联活菌治疗新生儿黄疸对患儿肠道菌群、胆红素水平的影响。方法:选取2021年5月-2023年5月于南京市江宁医院收治的300例黄疸患儿,采用随机数表法将患儿分为益生菌组和参照组,均纳入150例。参照组患儿采用常规治疗,益生菌组在参照组基础上加用双歧杆菌三联活菌散治疗,两组均持续治疗1周。比较两组患儿治疗效果,治疗前后肠道菌群、胆红素水平、炎症指标变化,以及两组患儿治疗期间的不良反应发生情况。结果:益生菌组治疗的有效率为90.67%,参照组为82.00%,差异有统计学意义(P<0.05)。治疗后,且益生菌组双歧杆菌、嗜酸乳杆菌水平高于参照组,益生菌组大肠杆菌水平低于参照组,差异有统计学意义(P<0.05);益生菌组总胆红素(TBIL)、直接胆红素(DBIL)和间接胆红素(IBIL)水平参照组低,差异均有统计学意义(P<0.05);益生菌组炎症水平较参照组低,差异有统计学意义(P<0.05);益生菌组γ-谷氨酰转移酶(GGT)和碱性磷酸酶(ALP)较参照组低,差异均有统计学意义(P<0.05)。益生菌组不良反应发生率为10.00%,参照组为12.00%,差异无统计学意义(P>0.05)。结论:双歧杆菌三联活菌治疗新生儿黄疸可以改善患儿肠道菌群和炎症水平,减轻患儿肝脏负担,降低胆红素水平。Objective:To explore the effects of Bifidobacterium triple viable bacteria on intestinal floras and bilirubin in neonatal jaundice.Methods:A total of 300 children with jaundice admitted to Nanjing Jiangning Hospital were enrolled between May 2021 and May 2023.According to random number table method,they were divided into probiotic group(Bifidobacterium triple viable bacteria tables on basis of control group)and control group(routine treatment),150 cases in each group.All were continuously treated for 1 week.The curative effect,changes of intestinal floras,bilirubin and inflammatory indexes before and after treatment,and the occurrence of adverse reactions during treatment were compared between the two groups.Results:The difference in response rate of treatment between probiotic group and control group was statistically significant(90.67%vs 82.00%,P<0.05).After treatment,counts of Bifidobacteria and Lactobacillus acidophilus in probiotic group were higher than those in control group,while count of Escherichia coli was lower than that in control group(P<0.05).The levels of total bilirubin(TBIL),direct bilirubin(DBIL)and indirect bilirubin(IBIL)in probiotic group were lower than those in control group(P<0.05),inflammation level was lower than that in control group(P<0.05),and levels ofγ-glutamyltransferase(GGT)and alkaline phosphatase(ALP)were lower than those in control group(P<0.05).There was no significant difference in incidence of adverse reactions between probiotic group and control group(10.00%vs 12.00%,P>0.05).Conclusion:Bifidobacterium triple viable bacteria can improve intestinal floras and inflammation level,reduce liver burden and bilirubin level in neonatal jaundice.

关 键 词：双歧杆菌三联活菌 新生儿黄疸 肠道菌群 胆红素水平 

分 类 号：R722.17[医药卫生—儿科]