糖尿病性黄斑水肿患者血清VEGF、MCP-1、Hcy的表达及其临床意义分析  

Expression and Clinical Significance of Serum VEGF,MCP-1 and Hcy in Patients with Diabetic Macular Edema

作　　者：李巧 陈基黎 王雷 张照委 孙梅 LI Qiao;CHEN Ji-li;WANG Lei;ZHANG Zhao-wei;SUN Me(Department of Ophthalmology,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu,221000,China)

机构地区：[1]徐州医科大学附属医院眼科,江苏徐州221000

出　　处：《现代生物医学进展》2024年第19期3778-3780,共3页Progress in Modern Biomedicine

基　　金：江苏省高等学校自然科学研究项目(20KJA160426)。

摘　　要：目的:探讨糖尿病性黄斑水肿(DME)患者血清血管内皮生长因子(VEGF)、单核细胞趋化因子蛋白-1(MCP-1)、同型半胱氨酸(Hcy)的表达及其临床意义。方法:选取2020年3月-2022年3月在我院治疗的115例DME患者纳入DME组,收集同期在我院门诊治疗的无DME的单纯2型糖尿病(T2DM)患者80例纳入对照组。对比两组的血清VEGF、MCP-1、Hcy水平。收集两组临床资料,采用单因素和多因素Logistic回归分析DME发病的影响因素。结果:DME组的血清VEGF、MCP-1、Hcy水平高于对照组(P<0.05)。DME发病与高密度脂蛋白(HDL-C)、性别、甘油三酯(TG)、低密度脂蛋白(LDL-C)、空腹血糖、体质量指数(BMI)、尿素氮、年龄、肌酐无关(P>0.05),而与糖尿病病程、糖化血红蛋白、总胆固醇(TC)有关(P<0.05)。多因素Logistic回归分析结果显示,糖尿病病程偏长、TC偏高、血清VEGF偏高、MCP-1偏高、Hcy偏高是DME发病的危险因素(P<0.05)。结论:DME患者血清VEGF、MCP-1、Hcy升高,血清VEGF、MCP-1、Hcy是DME发生的影响因素。Objective:To investigate the expression and clinical significance of serum vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1)and homocysteine(Hcy)in patients with diabetic macular edema(DME).Methods:115 DME patients who were treated in our hospital from March 2020 to March 2022 were selected as DME group,and 80 patients with type 2 diabetes mellitus(T2DM)without DME who were treated in our hospital during the same period were collected as control group.The levels of serum Hcy,VEGF and MCP-1 in control group and DME group were compared.Clinical data from both groups were collected,and univariate and multivariate Logistic regression was used to analyze the factors affecting the onset of DME.Results:The levels of serum Hcy,VEGF and MCP-1 in DME group were higher than those in control group(P<0.05).The incidence of DME was not related to high density lipoprotein(HDL-C),gender,triglyceride(TG),low density lipoprotein(LDL-C),fasting blood glucose,body mass index(BMI),urea nitrogen,age and creatinine(P>0.05),but was related to the course of diabetes mellitus,glycosylated hemoglobin and total cholesterol(TC)(P<0.05).Multivariate Logistic regression analysis showed that,longer duration of diabetes mellitus,higher TC,higher serum Hcy,higher VEGF and higher MCP-1 were risk factors for DME(P<0.05).Conclusion:The levels of serum Hcy,VEGF and MCP-1 in DME patients are increase,and serum Hcy,VEGF and MCP-1 are the influencing factors of DME.

关 键 词：糖尿病性黄斑水肿 血管内皮生长因子 单核细胞趋化因子蛋白-1 同型半胱氨酸 

分 类 号：R587.2[医药卫生—内分泌]