小儿柴桂退热颗粒治疗急性上呼吸道感染的疗效及安全性系统评价与meta分析  

Clinical efficacy and safety of Xiao'er Chaigui Tuire Granules in the treatment of acute upper respiratory tract infection:a meta-analysis

作　　者：李云[1] 常文婧 张煦东 张居文 陈薇[1] LI Yun;CHANG Wenjing;ZHANG Xudong;ZHANG Juwen;CHEN Wei(Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学循证医学中心,北京100029

出　　处：《中华全科医学》2024年第11期1957-1962,共6页Chinese Journal of General Practice

基　　金：国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202208)。

摘　　要：目的系统评价小儿柴桂退热颗粒单用或联用西药治疗急性上呼吸道感染的临床疗效及安全性,为临床应用提供循证依据。方法检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed和Cochrane Library各大数据库中应用小儿柴桂退热颗粒的临床研究文献,检索时限均为建库至2023年1月。对纳入文献进行数据提取,并采用方法学质量评估工具评价文献质量,运用RevMan 5.4软件进行meta分析。结果共纳入20项随机对照试验,共计2913例患者,meta分析结果显示,小儿柴桂退热颗粒联用利巴韦林可以缩短患儿的退热时间[MD=-0.75(d),95%CI:-1.00~-0.50,P<0.001];小儿柴桂退热颗粒联用阿莫西林也可以缩短患儿的退热时间[MD=-1.78(h),95%CI:-2.07~-1.48,P<0.001];与常规的抗生素、抗病毒治疗相比,小儿柴桂退热颗粒可缩短退热时间[MD=-0.95(d),95%CI:-1.44~-0.46,P<0.001];与单用利巴韦林相比,单用小儿柴桂退热颗粒疗效指标无明显优势。结论小儿柴桂退热颗粒联用西药有较好的治疗效果,但由于临床研究数量较少且质量有待提高,未来应规范临床试验开展的过程,提高证据质量,以指导小儿柴桂更好地应用于临床实践。Objective To systematically evaluate the clinical efficacy and safety of Xiao'er Chaigui Tuire Granules alone or combined with Western medicine in the treatment of acute upper respiratory tract infection,and to provide evidence-based basis for clinical application.Methods The clinical literatures on the application of Xiao'er Chaigui Tuire Granules were searched in CNKI,Wanfang,VIP,SinoMed,PubMed and Cochrane Library,and the retrieval time was established until January 2023.Data extraction were extracted from the included literatures,and methodological quality assessment tools were used to evaluate literature quality.Meta-analysis was performed using RevMan 5.4 software.Results A total of 2913 patients were included in 20 randomized controlled trials.The results of meta-analysis showed that Xiao'er Chaigui Tuire Granules combined with ribavirin could shorten the antipyretic time[MD=-0.75(d),95%CI:-1.00 to-0.50,P<0.001],Xiao'er Chaigui Tuire Granules combined with amoxicillin could also shorten the antipyretic time[MD=-1.78(h),95%CI:-2.07 to-1.48,P<0.001].Compared with the conventional antibiotics and antiviral agents,Xiao'er Chaigui Tuire Granules could shorten the antipyretic time[MD=-0.95(d),95%CI:-1.44 to-0.46,P<0.001].Compared with ribavirin,the therapeutic indexes of Xiao'er Chaigui Tuire Granules alone had no obvious advantage.Conclusion Xiao'er Chaigui Tuire Granules combined with Western medicine has a good therapeutic effect,whereas the number and quality of the relevant clinical studies remain to be improved.The process of clinical trial should be standardized to improve the quality of evidence,so to guide the better application of Xiao'er Chaigui Tuire Granules in clinical practice.

关 键 词：急性上呼吸道感染 小儿柴桂退热颗粒 META分析 

分 类 号：R725.6[医药卫生—儿科]