当归芍药散加减联合中药灌肠治疗慢性盆腔炎临床研究  

Clinical Study on Combination Use of Modified Danggui Shaoyao Powder and Chinese Medicine Enema for Chronic Pelvic Inflammatory Disease

作　　者：毛惠学 朱文敏 MAO Huixue;ZHU Wenmin(Department of Gynaecology and Obstetrics,Deqing Hospital of Traditional Chinese Medicine,Deqing Zhejiang 313200,China;Department of Chinese Medicine,Deqing Hospital of Traditional Chinese Medicine,Deqing Zhejiang 313200,China)

机构地区：[1]德清县中医院妇产科,浙江德清313200 [2]德清县中医院中医科,浙江德清313200

出　　处：《新中医》2024年第22期15-19,共5页New Chinese Medicine

摘　　要：目的:观察当归芍药散加减联合中药灌肠治疗慢性盆腔炎的临床疗效及对炎症因子的影响。方法:采用随机数字表法将90例慢性盆腔炎患者分为观察组与对照组各45例。对照组给予左氧氟沙星、甲硝唑治疗,观察组在对照组基础上加用当归芍药散加减联合中药灌肠治疗。比较2组治疗前后中医证候评分、简易生活质量评估量表(SF-36)评分及血清炎症因子[C-反应蛋白(CRP)、白细胞介素(IL)-2、IL-6、肿瘤坏死因子-α(TNF-α)]水平,并评估2组临床疗效、疾病复发及不良反应发生情况。结果:治疗后,观察组总有效率97.78%,高于对照组71.11%(P<0.05)。治疗后,2组中医证候评分及血清CRP、IL-2、IL-6、TNF-α水平均较治疗前降低(P<0.05),SF-36评分均升高(P<0.05);观察组治疗后中医证候评分及血清各炎症因子水平均低于对照组(P<0.05),SF-36评分高于对照组(P<0.05)。观察组不良反应发生率、疾病复发率分别为4.44%、3.12%,对照组不良反应发生率、疾病复发率分别为17.78%、21.74%,2组比较,差异有统计学意义(P<0.05)。结论:当归芍药散加减联合中药灌肠治疗慢性盆腔炎临床疗效显著,能够有效减轻患者炎症反应,提升生活质量,减少疾病复发,安全性较高。Objective:To observe the clinical effect of the combination use of modified Danggui Shaoyao Powder and Chinese medicine enema on chronic pelvic inflammatory disease and its effect on inflammatory factors.Methods:A total of 90 patients with chronic pelvic inflammatory disease were divided into the observation group and the control group according to the random number table method,with 45 cases in each group.The control group was treated with Levofloxacin and Metronidazole,and the observation group was additionally treated with modified Danggui Shaoyao Powder combined with Chinese medicine enema based on the treatment of the control group.The traditional Chinese medicine(TCM)syndrome scores,scores of 36-item health survey(SF-36)and levels of serum inflammatory factors[C-reactive protein(CRP),interleukin(IL)-2,IL-6 and tumor necrosis factor-α(TNF-α)]were compared before and after treatment between the two groups;the clinical effects,recurrence rates and incidence of adverse reactions in the two groups were evaluated.Results:After treatment,the total effective rate was 97.78%in the observation group,higher than that of 71.11%in the control group(P<0.05).After treatment,the TCM syndrome scores and the levels of serum CRP,IL-2,IL-6 and TNF-αin the two groups were decreased when compared with those before treatment(P<0.05),and the SF-36 scores were increased(P<0.05);after treatment,the TCM syndrome scores and the levels of serum inflammatory factors in the observation group were lower than those in the control group(P<0.05),and the SF-36 scores was higher than that in the control group(P<0.05).The incidence of adverse reactions and the recurrence rate were respectively 4.44%and 3.12%in the observation group and 17.78%and 21.74%in the control group,the difference being significant(P<0.05).Conclusion:The combination use of modified Danggui Shaoyao Powder and Chinese medicine enema has a significant clinical effect on chronic pelvic inflammatory disease,which can effectively mitigate the inflammatory responses of patien

关 键 词：慢性盆腔炎 当归芍药散 中药灌肠 炎症因子 生活质量 

分 类 号：R711[医药卫生—妇产科学]