止咳散联合超声药透疗法治疗慢性阻塞性肺疾病急性加重期临床研究  

Clinical Study on Zhike Powder Combined with Ultrasonic Drug Penetration Therapy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：袁大陆 尉理梁 尹灵巧 白莉娜 陈圆芳 郦梦琳 YUAN Dalu;WEI Liliang;YIN Lingqiao;BAI Li'na;CHEN Yuanfang;LI Menglin(Rehabilitation Medicine Department,Affiliated Hospital of Shaoxing University,Shaoxing Zhejiang 312000,China)

机构地区：[1]绍兴文理学院附属医院康复医学科,浙江绍兴312000

出　　处：《新中医》2024年第22期63-67,共5页New Chinese Medicine

摘　　要：目的:观察自拟止咳散配合超声药物透入疗法治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:将208例AECOPD患者按简单随机化法分为治疗组与对照组各104例,治疗组与对照组各剔除2例,最终2组各完成研究102例。对照组给予常规综合对症治疗,治疗组在对照组基础上给予止咳散联合超声药物透入疗法治疗。7 d为1个疗程,连续治疗2个疗程后评估2组临床疗效、中医证候评分、症状缓解时间、呼吸困难程度、血气指标及住院时间。结果:治疗组总有效率为94.12%,对照组为85.29%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分、改良Borg评分均较治疗前降低(P<0.05),且治疗组中医证候评分、改良Borg评分均低于对照组(P<0.05)。治疗后,治疗组喘息缓解时间、咳嗽缓解时间、肺部啰音消失时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,2组动脉血氧分压(PaO_(2))水平均较治疗前升高(P<0.05),动脉血二氧化碳分压(PaCO_(2))水平较治疗前降低(P<0.05);且治疗组PaO_(2)水平高于对照组(P<0.05),PaCO_(2)水平低于对照组(P<0.05)。结论:止咳散配合超声药透疗法治疗AECOPD痰热蕴肺型疗效确切,可加速临床症状体征缓解,并能改善呼吸困难及血气指标,缩短住院时间。Objective:To observe the clinical efficacy of self-made Zhike Powder combined with ultrasonic drug penetration therapy in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 208 cases of patients with AECOPD were randomly divided into the treatment group and the control group(104 cases in each group),with two patients excluded from each group,leaving 102 patients in each group for the final study.The control group received conventional comprehensive symptomatic treatment,and the treatment group received Zhike Powder combined with ultrasonic drug penetration therapy based on the control group's treatment.After two consecutive treatment courses,the clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,symptom relief time,degree of respiratory difficulty,blood gas indicators,and hospitalization time in the two groups were evaluated.Results:The total effective rate was 94.12%in the treatment group and 85.29%in the control group,with a significant difference(P<0.05).After treatment,TCM syndrome scores and modified Borg scores in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the relief time of wheezing and coughing,the disappearance time of pulmonary rales,and the hospitalization time in the treatment group were all shorter than those in the control group,with a significant difference(P<0.05).Before treatment,there was no significant difference in levels of after treatment,the levels of partial pressure of oxygen in artery(PaO_(2))in the two groups were elevated when compared with those before treatment(P<0.05),and the levels of partial pressure of carbon dioxide in artery(PaCO_(2))were reduced when compared with those before treatment(P<0.05);the PaO_(2) level in the treatment group was higher than that in the control group(P<0.05),and the PaCO_(2) level was lower than that in the control group(P<0.05).Conclusion:The

关 键 词：慢性阻塞性肺疾病 急性加重期 止咳散 超声药物透入疗法 改良Borg评分 血气分析 

分 类 号：R563[医药卫生—呼吸系统]