芪蛭益肾胶囊联合前列地尔治疗糖尿病肾病临床研究  

Clinical Study on Qizhi Yishen Capsules Combined with Alprostadil for Diabetic Kidney Disease

作　　者：周宗星 陈雪妹 ZHOU Zongxing;CHEN Xuemei(Nephrology Department,Pinghu Second People'Hospital,Pinghu Zhejiang 314201,China)

机构地区：[1]平湖市第二人民医院肾内科,浙江平湖314201

出　　处：《新中医》2024年第22期75-79,共5页New Chinese Medicine

摘　　要：目的:观察芪蛭益肾胶囊联合前列地尔治疗糖尿病肾病(DKD)的临床疗效及对肾脏微循环的影响。方法:选择早期DKD患者90例,按随机数字表法分为对照组与治疗组各45例。对照组给予前列地尔治疗,治疗组在对照组基础上加用芪蛭益肾胶囊治疗。比较2组临床疗效、肾功能[血肌酐(SCr)、尿素氮(BUN)、24 h尿蛋白定量(24h Upro)]、肾脏微循环指标[内皮素-1(ET-1)、血栓素B2(TXB2)、一氧化氮(NO)]及不良反应情况。结果:治疗组总有效率为95.56%,对照组为77.78%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血清SCr、BUN、24h Upro水平均较治疗前降低(P<0.05),且治疗组各项肾功能指标水平均低于对照组(P<0.05)。治疗后,2组ET-1、TXB2水平较治疗前降低(P<0.05),NO水平较治疗前升高(P<0.05);且治疗组ET-1、TXB2水平低于对照组(P<0.05);NO水平高于对照组(P<0.05)。治疗组不良反应发生率为13.33%,对照组为17.78%,2组比较,差异无统计学意义(P>0.05)。结论:芪蛭益肾胶囊联合前列地尔能够有效提高DKD患者的肾功能,改善肾脏微循环,提高临床疗效。Objective:To observe the clinical effect of Qizhi Yishen Capsules combined with Alprostadil on diabetic kidney disease(DKD)and the impact on renal microcirculation.Methods:A total of 90 cases of early-stage DKD patients were selected and divided into the control group and the treatment group according to the random number table method,with 45 patients in each group.The control group was treated with Alprostadil,and the treatment group was additionally treated with Qizhi Yishen Capsules based on the treatment of the control group.Clinical effects,kidney function[serum creatinine(SCr),blood urea nitrogen(BUN),and 24-hour urinary protein quantification(24-hour Upro)],renal microcirculation indicators[endothelin-1(ET-1),thromboxane B2(TXB2),and nitric oxide(NO)],and adverse reactions were compared between the two groups.Results:The total effective rate was 95.56%in the treatment group and 77.78%in the control group,with significance in the difference(P<0.05).After treatment,the levels of serum SCr,BUN,and 24-hour Upro in the two groups were decreased when compared with those before treatment(P<0.05),and each kidney function indicator in the treatment group was lower than that in the control group(P<0.05).After treatment,the levels of ET-1 and TXB2 in the two groups were declined when compared with those before treatment(P<0.05),and the levels of NO were increased when compared with those before treatment(P<0.05);the levels of ET-1 and TXB2 in the treatment group were lower than those in the control group(P<0.05);the level of NO in the treatment group was higher than that in the control group(P<0.05).The incidence of adverse reactions was 13.33%in the treatment group and 17.78%in the control group,with no significance in the difference(P>0.05).Conclusion:Qizhi Yishen Capsules combined with Alprostadil can effectively improve kidney function,renal microcirculation,and clinical effects in treating DKD patients.

关 键 词：糖尿病肾病 芪蛭益肾胶囊 前列地尔 肾功能 肾脏微循环 

分 类 号：R587.2[医药卫生—内分泌]