逍遥丸对肝气郁结证遗忘型轻度认知功能障碍患者认知功能和空间工作记忆的影响及神经电生理机制  

Effects and neuroelectrophysiological mechanism of Xiaoyao Pills on cognitive function and spatial working memory of amnestic mild cognitive impairment patients with liver-qi stagnation syndrome

作　　者：李宁[1,2,3] 秦中朋 刘永 赵紫薇[1,2,3] 侯俊林 詹向红 LI Ning;QIN Zhongpeng;LIU Yong;ZHAO Ziwei;HOU Junlin;ZHAN Xianghong(Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Engineering Technology Research Center for Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Brain Cognitive Diseases,Zhengzhou 450046,China;Zhengzhou Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Brain Cognitive Diseases,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,郑州450046 [2]河南省中西医结合防治脑认知疾病工程技术研究中心,郑州450046 [3]郑州市中西医结合防治脑认知疾病重点实验室,郑州450046

出　　处：《中华中医药杂志》2024年第11期6106-6112,共7页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.81873208);河南省“双一流”创建学科中医学科学研究专项(No.HSRP-DFCTCM-2023-1-02);河南中医药大学博士科研基金项目(No.BSJJ2020-02)。

摘　　要：目的:探讨逍遥丸干预肝气郁结证遗忘型轻度认知功能障碍(aMC I)患者总体认知功能和空间工作记忆的疗效及神经电生理机制。方法:采用问卷调查法筛选认知正常志愿者和具有6个月以上肝气郁结症状的aMCI患者,按照性别、年龄(±3岁)和受教育年限(±3年)相匹配原则,纳入认知正常组(正常组)、肝气郁结证aMCI用药组(用药组)和肝气郁结证aMCI非用药组(非用药组)各30例,用药组给予中成药逍遥丸治疗12周,正常组和非用药组不做药物干预。分别在12周前后对3组进行总体认知功能评估、空间工作记忆行为学测试和事件相关电位(ERPs)检测。结果:与本组12周前比较,用药组用药后MoCA总分以及视空间与执行功能、延迟回忆和定向3个认知域得分均升高(P<0.01),空间工作记忆行为学正确率升高(P<0.05),N2波幅变小(P<0.05),P3波幅升高(P<0.01)。同期各组间比较,12周前,用药组和非用药组的P3波幅均小于正常组(P<0.05);12周后,用药组的空间工作记忆行为学正确率和P3波幅均大于非用药组(P<0.05)。结论:逍遥丸可明显提高肝气郁结证aMCI患者的总体认知功能以及视空间与执行功能、延迟回忆和定向3个认知域水平,提升其空间工作记忆加工处理效率,以上可能与改善其空间工作记忆刺激识别注意分配能力以及信息编码储存能力等机制有关。Objective:To investigate the efficacy and neuroelectrophysiological mechanism of Xiaoyao Pills on the overall cognitive function and spatial working memory of patients with amnestic mild cognitive impairment(aMCI)with liverqi stagnation syndrome.Methods:Questionnaire survey was used to screen volunteers with normal cognitive function and aMCI patients with symptoms of liver-qi stagnation syndrome for more than 6 months.Subjects with normal cognitive function(normal group),medication subjects of aMCI with liver-qi stagnation syndrome(medication group)and non-medication subjects of aMCI with liver-qi stagnation syndrome(non-medication group)were included with 30 subjects in each group,according to the principle of matching gender,age(±3 years)and years of education(±3 years).The medication group was treated with Xiaoyao Pills,a Chinese patent medicine,for 12 weeks,and the normal group and non-medication group were not given drug intervention.Global cognitive function assessment,spatial working memory behavioral testing and event-related potentials(ERPs)testing were performed in the three groups before and after 12 weeks.Results:Compared with this group 12 weeks before,the total score of MoCA and the scores of the three cognitive domains of visual space and executive function,delayed recall and orientation increased in the drug group after 12 weeks of treatment(P<0.01),increased correct rate of spatial working memory behavioral behavior(P<0.05),the amplitude of N2 becomes smaller(P<0.05)and the amplitude of P3 increases(P<0.01).Comparison between groups during the same period,before 12 weeks,the amplitude of P3 in the medication group and the non-medication group was lower than that in the normal group(P<0.05);After 12 weeks,the behavioral correctness rate of spatial working memory and P3 amplitude in the medication group were higher than those in the non-medication group(P<0.05).Conclusion:Xiaoyao Pills can significantly improve the overall cognitive function,visual space and executive function,delayed recall and

关 键 词：逍遥丸 肝气郁结证 遗忘型轻度认知功能障碍 空间工作记忆 神经电生理机制 

分 类 号：R277.7[医药卫生—中医学]