基于对应分析的频发室性早搏中医证候与合并病的相关性研究  

Research on the correlation between traditional Chinese medicine syndromes and comorbidities in patients with frequent premature ventricular complexes based on correspondence analysis

作　　者：于珊珊 何庆勇[1] 孟甜甜 宋昕宾 刘锦 李一翔 但文超 孟培培 YU Shanshan;HE Qingyong;MENG Tiantian;SONG Xinbin;LIU Jin;LI Yixiang;DAN Wenchao;MENG Peipei(Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China;Graduate School of Henan University of Chinese Medicine,Zhengzhou 450046,China;Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学东方医院,北京100078 [3]河南中医药大学研究生院,郑州450046 [4]首都医科大学附属北京中医医院,北京100010

出　　处：《中华中医药杂志》2024年第11期6140-6143,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局2020年中医药古籍文献和特色技术传承专项项目(No.GZY-KJS-2020-079);北京中医药大学孙思邈研究院2020年度中医药科研计划资助项目(No.SSMYJY-1-2020-03);首都临床特色诊疗技术研究及转化应用(No.Z221100007422081)。

摘　　要：目的:探究频发室性早搏患者中医证候与合并病的相关性,为临床辨证施治提供较为可靠的参考依据。方法:采用多中心横断面调查方法收集频发室性早搏患者,应用SAS 9.4软件进行对应分析研究。结果:1002例频发室性早搏患者中最常见的证候是气阴两虚证283例(28.24%)、心脾两虚证267例(26.65%)、阴阳两虚证235例(23.45%)。在频发室性早搏的合并病中,冠心病与阴阳两虚证的关系最为紧密(相关距离为0.059542),高血压与心阳不振证的关系最为紧密(相关距离为0.023602),2型糖尿病与痰火扰心证的关系最为紧密(相关距离为0.011741)。结论:频发室性早搏的治疗除益气养阴、补益心脾、滋阴通阳外,还应根据频发室性早搏的合并病辨证论治,如频发室性早搏合并冠心病时应滋阴通阳,合并高血压应温通心阳,合并2型糖尿病应清火化痰,以期获得更好疗效。Objective:To explore the correlation between traditional Chinese medicine(TCM)syndromes and comorbidities in patients with frequent premature ventricular complexes(PVCs),and provide a reliable guideline for clinical syndrome differentiation.Methods:A multicenter cross-sectional study was conducted to collect patients with frequent PVCs.SAS 9.4 software was applied for the corresponding analysis.Results:A total of 1002 patients with frequent PVCs were included,of which,the most common TCM syndromes were dual deficiency of qi and yin[283 cases(28.24%)],followed by dual deficiency of heart and spleen[267 cases(26.65%)]and dual deficiency of yin and yang[235 cases(23.45%)].In addition,among patients with frequent PVCs complicated with other diseases,frequent PVCs complicated with coronary heart disease was most closely associated with dual deficiency of qi and yin syndrome(correlation distance:0.059542),frequent PVCs complicated with hypertension was most closely associated with heart-yang deficiency syndrome(correlation distance:0.023602),and frequent PVCs complicated with type 2 diabetes was most closely associated with the phlegm-fire disturbance heart syndrome(correlation distance:0.011741).Conclusion:The treatment of frequent PVCs is invigorating qi and yin,nourishing heart and spleen,nourishing yin and activating yang.It should also be treated according to the syndrome differentiation of frequent PVCs.Frequent PVCs combined with coronary heart disease should be based on nourishing yin and tonifying yang,combined with hypertension should be based on warming heart yang,combined with type 2 diabetes should be based on clearing fire and resolving phlegm.

关 键 词：频发室性早搏 心悸 中医证候 合并病 对应分析 

分 类 号：R259[医药卫生—中西医结合]