血清STNFR-Ⅱ、KIM-1、β2-MG水平与妊娠期高血压疾病患者早期肾损伤的相关性分析  

Analysis on Correlation betwween Serum STNFR-Ⅱ,KIM-1,β2-MG Levels and Early Renal Injury in Patients with Gestational Hypertension

作　　者：赵太坤 郭伟 ZHAO Taikun;GUO Wei(Department of Obstetrics,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China)

机构地区：[1]郑州大学附属洛阳中心医院产科,河南洛阳471000

出　　处：《临床医学工程》2024年第11期1391-1392,共2页Clinical Medicine & Engineering

摘　　要：目的分析血清STNFR-Ⅱ、KIM-1、β2-MG水平与妊娠期高血压疾病患者早期肾损伤的相关性。方法选取我院2021年2月至2023年11月收治的100例妊娠期高血压疾病患者纳入研究组,另选取同期我院100例健康妊娠期女性纳入参照组。比较研究组和参照组以及研究组中合并与未合并早期肾损伤患者的血清STNFR-Ⅱ、KIM-1、β2-MG水平,并分析血清STNFR-Ⅱ、KIM-1、β2-MG水平与妊娠期高血压患者发生早期肾损伤的相关性。结果研究组血清STNFR-Ⅱ、KIM-1、β2-MG水平高于参照组(P<0.05)。研究组中合并早期肾损伤患者的血清STNFR-Ⅱ、KIM-1、β2-MG水平高于未合并早期肾损伤患者(P<0.05)。Spearman相关性分析结果显示,血清STNFR-Ⅱ、KIM-1、β2-MG水平与妊娠期高血压疾病患者早期肾损伤呈明显正相关(r=0.621、0.583、0.604,P=0.000、0.000、0.000)。结论血清STNFR-Ⅱ、KIM-1、β2-MG水平与妊娠期高血压疾病患者发生早期肾损伤关系密切,临床可通过检测妊娠期高血压疾病患者血清STNFR-Ⅱ、KIM-1、β2-MG水平评估其是否发生早期肾损伤。Objective To analyze the correlation between serum STNFR-Ⅱ,KIM-1,β2-MG levels and early renal injury in patients with gestational hypertension.Methods 100 patients with gestational hypertension admitted to our hospital from February 2021 to November 2023 were selected as the study group,and 100 healthy pregnant women in our hospital during the same period were selected as the reference group.The serum STNFR-Ⅱ,KIM-1 andβ2-MG levels were compared between the study group and the reference group,as well as between patients with and without early renal injury in study group.The correlation between serum STNFR-Ⅱ,KIM-1,β2-MG levels and early renal injury in patients with gestational hypertension was analyzed.Results The serum STNFR-Ⅱ,KIM-1 andβ2-MG levels in the study group were higher than those in the reference group(P<0.05).The serum STNFR-II,KIM-1 andβ2-MG levels in patients with early renal injury of the study group were higher than those in patients without early renal injury(P<0.05).Spearman correlation analysis results showed that serum STNFR-Ⅱ,KIM-1 andβ2-MG levels were significantly positively correlated with early renal injury in patients with gestational hypertension(r=0.621,0.583,0.604,P=0.000,0.000,0.000).Conclusions Serum STNFR-Ⅱ,KIM-1 andβ2-MG levels are closely related to early renal injury in patients with gestational hypertension.Clinically,whether early kidney injury occurs can be evaluated by detecting serum STNFR-Ⅱ,KIM-1 andβ2-MG levels of patients with gestational hypertension.

关 键 词：STNFR-Ⅱ KIM-1 Β2-MG 妊娠期高血压疾病 早期肾损伤 

分 类 号：R714.246[医药卫生—妇产科学]