金丹附延颗粒治疗甲状腺癌侧颈淋巴结清扫术后难治性乳糜漏的疗效(附3例报道)  

Clinical effect of refractory chylous leakage treated by Jindan Fuyan Granule after neck lymph node dissection for thyroid cancer:a report of 3 cases

作　　者：郭南南 姚樟燠 琚国园 桂波 姚卫萍[1] 郝汉霞[1] 陈伟[1] 赵炎斌[1] 钱亦淳[1] 刘方舟[1] GUO Nannan;YAO Zhangyu;JU Guoyuan;GUI Bo;YAO Weiping;HAO Hanxia;CHEN Wei;ZHAO Yanbin;QIAN Yichun;LIU Fangzhou(Department of Head and Neck Surgery,Jiangsu Cancer Hospital,Nanjing 210009,P.R.China)

机构地区：[1]江苏省肿瘤医院头颈外科,南京210009

出　　处：《中国普外基础与临床杂志》2024年第11期1319-1323,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金面上项目(项目编号:81972555);江苏省自然科学基金面上项目(项目编号:BK20241991)。

摘　　要：目的 总结应用金丹附延颗粒治疗甲状腺癌颈淋巴结清扫术后难治性乳糜漏的安全性及临床疗效。方法 回顾性收集2023年1月至12月期间于江苏省肿瘤医院头颈外科接受金丹附延颗粒治疗的3例甲状腺癌颈淋巴结清扫术后难治性乳糜漏患者的临床病例资料。结果 3例甲状腺癌颈淋巴结清扫术后难治性乳糜漏患者在常规治疗的基础上联合金丹附延颗粒治疗后,乳糜引流量均明显减少,分别从100 mL减少到2 mL、1 285 mL减少到5 mL、960 mL减少到5 mL,治疗3 d后均顺利拔管。治疗期间,3例患者生命体征平稳,心电图未出现异常,1例出现恶心、胃部不适,给予处理后不适消失。患者出院后,对3例患者进行随访(分别随访3、3、4个月),患者伤口愈合良好,未出现乳糜液漏出或其他不适情况。结论 配合低脂饮食、引流等其他非手术治疗方法,金丹附延颗粒治疗甲状腺癌颈淋巴结清扫术后难治性乳糜漏的效果明显,可以作为非手术治疗的药物选择,但疗效还需进一步验证。Objective To summarize the efficacy and safety of Jindan Fuyan Granule in the treatment of refractory chylous leakage after neck lymph node dissection for thyroid cancer.Method The clinical data of thyroid cancer patients with refractory chylous leakage after neck lymph node dissection treated with Jindan Fuyan Granules in the Department of Head and Neck Surgery of Jiangsu Cancer Hospital from January to December 2023,were retrospectively collected.Results After treatment with Jindan Fuyan Granules on the basis of conventional treatment,the drainage volume of 3 patients with thyroid cancer after radical neck lymph node dissection was significantly reduced,from 100 mL to 2 mL,1285 mL to 5 mL,and 960 mL to 5 mL,respectively.After 3 days of treatment,the tubes were removed successfully.After discharge from the hospital,3 patients were followed up for 3,3,4 months,respectively,showing satisfactory wound healing without chylous leakage or other discomfort.Conclusions Combined with low-fat diet,drainage and other non-surgical treatment methods,Jindan Fuyan Granule has obvious effect on treating refractory chylous fistula after neck lymph node dissection,which can be used as a non-surgical treatment option.However,the efficacy needs to be further verified.

关 键 词：金丹附延颗粒 难治性乳糜漏 甲状腺癌 颈淋巴结清扫 

分 类 号：R273[医药卫生—中西医结合]