β-adrenergic regulation of Ca^(2+)signaling in heart cells  

作　　者：Bo Yang Shi-Qiang Wang Hua-Qian Yang 

机构地区：[1]Cyrus Tang Medical Institute,Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases,Soochow University,Suzhou,Jiangsu 215123,China [2]State Key Lab of Membrane Biology,College of Life Sciences,Peking University,Beijing 100871,China

出　　处：《Biophysics Reports》2024年第5期274-282,共9页生物物理学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(92254301,32230048 and 82270268);the Jiangsu Provincial Natural Science Foundation(BK20221358);the High Level Personnel Project of Jiangsu Province(JSSCBS20210696 and JSSCRC2022472)。

摘　　要：β-adrenergic receptors(βARs)play significant roles in regulating Ca^(2+)signaling in cardiac myocytes,thus holding a key function in modulating heart performance.βARs regulate the influx of extracellular Ca^(2+)and the release and uptake of Ca^(2+)from the sarcoplasmic reticulum(SR)by activating key components such as L-type calcium channels(LTCCs),ryanodine receptors(RyRs)and phospholamban(PLN),mediated by the phosphorylation actions by protein kinase A(PKA).In cardiac myocytes,the presence ofβ2AR provides a protective mechanism against potential overstimulation ofβ1AR,which may aid in the restoration of cardiac dysfunctions.Understanding the Ca^(2+)regulatory signaling pathways ofβARs in cardiac myocytes and the differences among variousβAR subtypes are crucial in cardiology and hold great potential for developing treatments for heart diseases.

关 键 词：β-adrenergic receptor(βAR) Ca^(2+)signaling Cardiac myocytes COMPARTMENTALIZATION 

分 类 号：Q257[生物学—细胞生物学]