T细胞亚群及其细胞因子在原发免疫性血小板减少症中作用的研究新进展  

Research advance on role of T-cell subsets and their cytokines in primary immune thrombocytopenia

作　　者：李娜[1] 童娟 Li Na;Tong Juan(Soochow University,the First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu Province,China;Department of Hematology,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,Anhui Province,China)

机构地区：[1]苏州大学苏州大学附属第一医院,苏州215006 [2]中国科学技术大学附属第一医院(安徽省立医院)血液内科,合肥230001

出　　处：《国际输血及血液学杂志》2024年第3期240-247,共8页International Journal of Blood Transfusion and Hematology

基　　金：吴阶平医学基金会临床科研专项资助基金项目(320.6750.2020-10-104);湖北陈孝平科技发展基金会资助项目(CXPJJH122002-060)。

摘　　要：原发免疫性血小板减少症(ITP)是以机体对血小板的免疫反应失调,影响血小板的破坏和产生为特征。由T细胞异常介导的免疫失耐受在ITP中发挥重要作用,主要表现为T细胞亚群平衡被破坏、骨髓中CD8+T细胞的募集增加、调节性T细胞(Treg)数量和功能的异常等。因此,阐明T细胞亚群及其细胞因子在ITP发病机制中的作用,针对不同发病阶段的ITP患者采取个体化治疗,将极大改善患者预后。笔者拟就T细胞亚群及其细胞因子在ITP患者病理、生理及治疗中作用的最新研究进展进行阐述,旨在为阐明ITP发病机制提供参考。Primary immune thrombocytopenia(ITP)is characterized by dysregulated immune responses against platelet,leading to platelet destruction and impaired platelet production.Abnormal T cell-mediated immune tolerance breakdown plays a crucial role in ITP,manifesting primarily as an imbalance in T cell subsets,increased recruitment of CD8+T cells in bone marrow,and abnormalities in quantity and function of regulatory T cell(Treg).Therefore,elucidating the role of T cell subsets and their cytokines in the pathogenesis of ITP and tailoring individualized treatment strategies based on different stages of the disease could significantly improve patients prognosis.This article aims to elaborate on the latest research progress on the role of T cell subsets and their cytokines in the pathophysiology and treatment of patients with ITP,providing insights into the underlying mechanisms of ITP.

关 键 词：紫癜 血小板减少性 特发性 T细胞亚群 细胞因子类 免疫耐受性 免疫性血小板减少症 

分 类 号：R558.2[医药卫生—血液循环系统疾病]