Nanotechnology-based tumor metabolic reprogramming:Insights into nutrient-delivery and metabolism reactivation therapy  

作　　者：Xi Hu Daishun Ling 

机构地区：[1]School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230038,China [2]Institute of Pharmaceutics,Anhui Academy of Chinese Medicine,Hefei 230038,China [3]Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application,Anhui University of Chinese Medicine,Hefei 230038,China [4]Frontiers Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,China [5]WLA Laboratories,Shanghai 201203,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第10期4619-4621,共3页药学学报（英文版）

摘　　要：Metabolic reprogramming in cancer is not only a core hallmark but also exposes treatment vulnerabilities.Several key processes required for tumor initiation and progression—continuous self-renewal,survival,and proliferation—are known to be under metabolic control^(1).Therapeutic opportunities arise from dysregulated metabolism and metabolic crosstalk,as tumor cells become heavily dependent on specific metabolic pathways such as glucose,amino acid,and fatty acid metabolism,as well as nucleotide synthesis^(2).However,many anti-metabolite drugs,including glycolysis inhibitors,have not been successfully applied in clinical settings due to their low specificity and undesirable side effects.

关 键 词：Metabolic therapy Metabolic reprogramming Cancer metabolism Metabolism reactivation therapy Melanin metabolism Nutrient-delivery Tumor therapy NANOTECHNOLOGY 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]