ROS-degradable polythioketal urethane scaffold for porcine wound repair  

作　　者：Salim Ullah Hong-Tao Xu Jianliang Shen 

机构地区：[1]The Fifth Affiliated Hospital of Wenzhou Medical University,Lishui 323020,China [2]National Engineering Research Center of Ophthalmology and Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou 325027,China [3]Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第10期4628-4631,共4页药学学报（英文版）

摘　　要：Porous,resorbable synthetic biomaterials such as polyesters provide a cost-effective framework for the healing of skin wounds.However,it must be optimized to reduce acidic breakdown and improve immunological and regenerative responses.Recently,Craig L.Duvall^(1) and his team published his work in Science Translational Medicine,which delineates the synthesis,characterization,and application of ethylene glycol(EG7)polythioketal urethane(PTK-UR).Here,they integrate seven ethylene glycol repeats unites in the PTK-UR polymer backbone to enhance its hydrophilicity and biological compatibility,facilitating optimal wound-healing processes in porcine skin models.These implants promote extracellular matrix(ECM)deposition,reepithelialization,and remodeling while effectively transitioning to a healing phenotype from a moderate inflammatory response.

关 键 词：(ROS)-degradable polythioketal HYDROPHILICITY Antioxidant Extracellular matrix deposition Ischemic wound healing 

分 类 号：R318.08[医药卫生—生物医学工程]