安络化纤丸对老年乙肝患者免疫因子的影响  

Effect of anluohuaxian pill on immune factors in elderly patients with hepatitis B

作　　者：易婷[1] 李洪[1] YI Ting;LI Hong(The Third People's Hospital of Changzhou,Changzhou 213000,China)

机构地区：[1]常州市第三人民医院,江苏常州213000

出　　处：《临床医药实践》2024年第11期806-809,842,共5页Proceeding of Clinical Medicine

基　　金：常州市卫生健康委员会科技项目(项目编号:ZD201815)。

摘　　要：目的:探讨安络化纤丸联合核苷酸类药物对老年乙型肝炎患者免疫功能和预后的影响。方法:选择2021年1月—2023年12月接受治疗的老年乙型肝炎患者148例,随机分为观察组和对照组,每组74例。对照组给予恩替卡韦口服,观察组在对照组基础上给予安络化纤丸口服。两组的疗程均为3个月,随访半年。比较两组肝功能、肝脏纤维化、炎症因子、免疫功能等血清学标志物和预后。结果:治疗前,两组肝功能、肝脏纤维化、炎症因子、免疫功能等血清学标志物比较,差异无统计学意义(P>0.05)。治疗后,两组的血清层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、血清透明质酸(HA)、Ⅳ型前胶原(Ⅳ-C)水平以及谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)血清水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的白蛋白(ALB)血清水平和分化簇3(CD3),CD4,CD4/CD8血清水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组的肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)和CD8血清水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。6个月内,观察组乙肝病毒的脱氧核糖核酸(HBV-DNA)转阴率和乙肝表面抗原(HBeAg)转阴率均高于对照组,差异有统计学意义(P<0.05)。结论:安络化纤丸联合核苷酸类药物可以促进老年乙肝患者免疫功能和肝功能恢复,减轻炎性反应和肝纤维化,改善预后。Objective:This study was aimed to explore the effects of AnluoHuaxian pill combined with nucleotide drugs on immune function and prognosis of elderly patients with hepatitis B.Methods:Elderly patients with hepatitis B treated in hospital from January 2021 to December 2023 were selected as the study objects.A total of 148 elderly patients with hepatitis B were included in this study and randomly divided into observation group and control group,with 74 patients in each group.The control group was given entecavir orally.The observation group was given anluohuxian pill orally on the basis of the treatment of the control group.The course of treatment in both groups was 3 months,and the follow-up was 6 months.The differences of serological markers such as liver function,liver fibrosis,inflammatory factors,immune function and prognosis were compared between the two groups.Results:Before treatment,there was no significant difference in serum markers of liver function,liver fibrosis,inflammatory factors and immune function between the two groups(P>0.05).After treatment,the levels of serum laminin(LN),procollagenⅢ(PCⅢ),hyaluronic acid(HA),procollagenⅣ(Ⅳ-C)and the levels of alanine transaminase(ALT),aspartate transaminase(AST)and total bilirubin(TbIL)in both groups were lower than those before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After treatment,the serum levels of albumin(ALB)and differentiation cluster 3(CD3),CD4,CD4/CD8 in the two groups were higher than those before treatment,and the serum levels in the observation group were higher than those in the control group(P<0.05).After treatment,the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),highsensitivity C-reactive protein(hs-CRP)and CD8 in both groups were lower than those before treatment,and the tumor necrosis factors levels in the observation group were lower than those in the control group,the difference was significant(P<0.05).Within 6 months,the DNA o

关 键 词：乙型肝炎 安络化纤丸 免疫因子 预后 

分 类 号：R512.62[医药卫生—内科学]