司库奇尤单抗联合卡泊三醇软膏治疗银屑病对患者症状的改善及护理体会  

Improvement of symptoms and nursing care experience of patients with psoriasis treated with combination therapy of scorgizumab and carpotriol

作　　者：徐丽华 谭剑萍 黄燕君 XU Lihua;TAN Jianping;HUANG Yanjun(Guangzhou Hospital of Dermatology,Guangzhou 510095,China)

机构地区：[1]广州市皮肤病医院,广东广州510095

出　　处：《临床医药实践》2024年第11期855-858,共4页Proceeding of Clinical Medicine

摘　　要：目的:探讨司库奇尤单抗联合卡泊三醇软膏治疗银屑病患者的临床疗效及相应的护理干预措施。方法:选择2021年1月—2022年12月门诊诊断的200例银屑病患者。根据随机数字表法分为对照组和观察组,每组100例。对照组予以卡泊三醇软膏治疗,观察组给予司库奇尤单抗联合卡泊三醇软膏治疗。对比两组临床疗效、症状改善时间、银屑病面积和严重程度指数(PASI)、血清相关指标及不良反应发生率。结果:观察组总有效率显著高于对照组(P<0.05);与对照组比较,观察组各项症状改善时间均较短(P<0.05);两组治疗后PASI评分均呈降低趋势,且观察组降低更明显(P<0.05);两组治疗后肿瘤坏死因子(TNF-α)、白介素-17(IL-17)、白介素-23(IL-23)均有不同程度的降低,且观察组降幅更大(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:司库奇尤单抗与卡泊三醇软膏联合治疗银屑病,疗效较为突出,可明显改善症状,缩小皮损面积,减轻炎症反应,配合有效的护理干预措施,可更好地保障治疗安全性。Objective:To explore the clinical efficacy and corresponding nursing interventions of the combined use of escuzumab and cabotriol in the treatment of psoriasis patients.Methods:All 200 patients with psoriasis from January 2021 to December 2022 were selected.They were divided into control group and observation group with 100 cases in each group.The control group were treated with cabotriol,the observation group were treated with the combination of skuchizumab and caspotriol.The clinical efficacy,symptom improvement time,psoriasis area and severity index(PASI),serum related indexes and adverse reaction rate were compared between the two groups.Results:The total effective rate of the observation group was significantly higher than the control group(P<0.05).Compared with the control group,the observation group had a shorter time for symptom improvement(P<0.05).After treatment,both groups showed a decreasing trend in PASI scores,and the observation group showed more significant changes(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-17(IL-17)and interleukin-23(IL-23)in both groups were decreased to some extent,and the tumor necrosis factors in the observation group was more significant than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:In the treatment of psoriasis,the combination of escuzumab and cabotriol has a prominent therapeutic effect,significantly improving the symptoms,reducing the area of skin lesions,reducing inflammatory reactions,and cooperating with effective nursing interventions can better ensure the safety of treatment.

关 键 词：司库奇尤单抗 卡泊三醇 银屑病 症状改善 护理 

分 类 号：R473.75[医药卫生—护理学]