Biofilms and exopolysaccharides in Pseudomonas aeruginosa:pathogenesis,immune evasion,and lung–brain signaling during pneumonia  

作　　者：Shuaibing Zhang Pierre Stallforth 

机构地区：[1]Department of Paleobiotechnology,Leibniz Institute for Natural Product Research and Infection Biology–Hans Knöll Institute,Beutenbergstraße 11a,D-07745 Jena,Germany [2]Institute for Organic Chemistry and Macromolecular Chemistry,Friedrich Schiller University Jena,Humboldtstraße 10,D-07743 Jena,Germany [3]Cluster of Excellence Balance of the Microverse,Friedrich Schiller University Jena,Fürstengraben 1,D-07743 Jena,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第9期3550-3551,共2页信号转导与靶向治疗（英文）

基　　金：supported by Deutsche Forschungsgemeinschaft(German Research Foundation)under Germany’s Excellence Strategy EXC 2051(Project-ID 390713860,“Balance of the Microverse”);-SFB1127/2 ChemBioSys—Project ID 239748522;the Werner Siemens Foundation.

摘　　要：A recent study by Granton et al.in Cell investigates the role of exopolysaccharide(EPS)in Pseudomonas aeruginosa’s biofilm formation,immune evasion,and lung–brain signaling during pneumonia.1 This research significantly advances our understanding of how P.aeruginosa’s biofilms influence disease symptoms and suggests potential therapeutic strategies targeting the lung–brain axis to improve clinical outcomes in pneumonia patients.Long before the COVID-19 pandemic,social distancing from individuals suffering from severe respiratory tract infections has been an effective strategy to limit the transmission of airborne diseases.2 In their work,Granton et al.investigate the specific mechanisms by which the bacterium P.aeruginosa triggers symptoms of sickness in individuals suffering from pneumonia.Understanding these mechanisms is vital as they directly influence the spread of the disease.Bacterial strains causing less noticeable sickness may result in symptoms undetected by others,eventually enhancing the transmission of the pathogen.

关 键 词：PNEUMONIA LUNG 

分 类 号：R563.1[医药卫生—呼吸系统]