Opioid receptors:single molecule studies shed light on mechanisms of efficacy  

作　　者：Cornelius Krasel Moritz Bünemann 

机构地区：[1]Institute for Pharmacology and Clinical Pharmacy,Philipps-University Marburg,Marburg,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第9期3555-3556,共2页信号转导与靶向治疗（英文）

基　　金：funding enabled and organized by Project DEAL.

摘　　要：In a study recently published in Nature,Zhao et al.1 investigate the conformational dynamics of theμ-opioid receptor(μOR).They found evidence for previously unknown conformations of this receptor which could eventually improve the therapy of severe pain.TheμOR is the primary target of opioids,the most potent painkillers available.However,their use is often complicated by undesirable side effects such as respiratory depression and addiction.

关 键 词：eventually conformational CONFORMATION 

分 类 号：R96[医药卫生—药理学]