Engineered Janus hydrogels:biomimetic surface engineering and biomedical applications  

作　　者：Mingfei Pan Tao Shui Ziqian Zhao Li Xiang Bin Yan Ning Gu Hongbo Zeng 

机构地区：[1]Department of Chemical and Materials Engineering,University of Alberta,Alberta T6G 1H9,Canada [2]Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine,Institute of Clinical Medicine,Nanjing Drum Tower Hospital,Medical School,Nanjing University,Nanjing 210093,China [3]Changzhou Second People’s Hospital,Changzhou Medical Center,Nanjing Medical University,Changzhou 213164,China [4]School of Materials Science and Engineering,Southeast University,Nanjing 211189,China [5]School of Mechanical Engineering,Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments,Southeast University,Nanjing 211189,China [6]National Engineering Laboratory for Clean Technology of Leather Manufacture,College of Biomass Science and Engineering,Sichuan University,Chengdu 610065,China

出　　处：《National Science Review》2024年第10期344-361,共18页国家科学评论（英文版）

基　　金：supported by the Canada Foundation for Innovation(CFI),the Natural Sciences and Engineering Research Council of Canada(NSERC),the Frontier Fundamental Research Program of Jiangsu Province for Leading Technology(BK20222002);the China Postdoctoral Science Foundation(2022M722198);the Medical-Industrial Integration Project of the Second Affiliated Hospital of Nanjing Medical University(YGRH005);the Basic Research Project of Changzhou Medical Center of Nanjing Medical University(CMCB202317);the Canada Research Chairs program(H.Zeng).

摘　　要：Hydrogel bioadhesives,when applied to dysfunctional tissues substituting the epidermis or endothelium,exhibit compelling characteristics that enable revolutionary diagnostic and therapeutic procedures.Despite their demonstrated efficacy,these hydrogels as soft implants are still limited by improper symmetric surface functions,leading to postoperative complications and disorders.Janus hydrogel bioadhesives with unique asymmetric surface designs have thus been proposed as a reliable and biocompatible hydrogel interface,mimicking the structural characteristics of natural biological barriers.In this comprehensive review,we provide guidelines for the rational design of Janus hydrogel bioadhesives,covering methods for hydrogel surface chemistry and microstructure engineering.The engineering of Janus hydrogels is highlighted,specifically in tuning the basal surface to facilitate instant and robust hydrogel-tissue integration and modulating the apical surface as the anti-adhesion,anti-fouling,and anti-wear barrier.These asymmetric designs hold great potential in clinical translation,supporting applications including hemostasis/tissue sealing,chronic wound management,and regenerative medicine.By shedding light on the potential of Janus hydrogels as bioactive interfaces,this review paper aims to inspire further research and overcome current obstacles for advancing soft matter in next-generation healthcare.

关 键 词：interfacial science BIONICS hydrogel bioadhesives asymmetric surfaces 

分 类 号：TQ427.26[化学工程]