MAPK信号通路对动物肠道紧密连接的调控研究进展  

Research Progress of MAPK Signaling Pathway on the Regulation of Intestinal Tight Junction in Animals

作　　者：冷来福 黄金秀[1,2] 陈志华 王琪 LENG Laifu;HUANG Jinxiu;CHEN Zhihua;WANG Qi(Chongqing Academy of Animal Sciences,Chongqing 402460,China;College of Animal Science and Technology,Southwest University,Chongqing 402460,China;Center of Technology Innovation for Pig(Chongqing),Chongqing 402460,China)

机构地区：[1]重庆市畜牧科学院,重庆402460 [2]西南大学动物科学技术学院,重庆402460 [3]生猪技术创新中心(重庆),重庆402460

出　　处：《中国畜牧杂志》2024年第11期62-68,共7页Chinese Journal of Animal Science

基　　金：重庆市自然科学基金面上项目(CSTB2022NSCQ-MS X0378);重庆市财政专项资金项目(23513C);国家生猪技术创新中心先导科技项目(NCTIP-XD-B04)。

摘　　要：肠道紧密连接(TJ)是肠上皮细胞之间的一种重要连接方式,也是构成肠道屏障的基础。丝裂原活化蛋白激酶(MAPK)信号通路广泛存在于机体的细胞和组织中,参与调节机体的大部分生理过程。研究证实,MAPK信号通路参与调节动物肠道TJ功能。本文综述了MAPK信号通路对动物肠道TJ的影响及调控机制,旨在为通过MAPK信号通路改善动物肠道屏障损伤提供新思路。Intestinal tight junction(TJ)is an important connection between intestinal epithelial cells and the basis for the intestinal barrier.Mitogen-activated protein kinase(MAPK)signaling pathway widely distributed in cells and tissues,and is involved in regulating most physiological processes of the body.Studies have demonstrated that the MAPK signaling pathway is participated in regulating of intestinal TJ function in animals.This paper reviews the effects and regulatory mechanisms of the MAPK signaling pathway on animal intestinal TJ,which aim to provide new insights for improving intestinal barrier damage in animals through the MAPK signaling pathway.

关 键 词：肠道紧密连接 MAPK信号通路 蛋白激酶 肠道屏障 

分 类 号：S811.2[农业科学—畜牧学]