猫过敏原Fel d 1研究进展  

Research Progress of Cats Allergen Fel d 1

作　　者：田宏凯 李琛琛 李巴仑 赵献军 华进联[1] TIAN Hongkai;LI Chenchen;LI Balun;ZHAO Xianjun;HUA Jinlian(College of Veterinary Medicine,Northwest A&F University/Stem Cell Engineering Technology Research Center of Shaanxi Province,Yangling 712100,China;Pet Stem Cells Research Institute of Northwest A&F University and BaiOuPai(Tianjin)Biotechnology Co.,Ltd,Jinnan District,Tianjin 300350,China)

机构地区：[1]西北农林科技大学动物医学院/陕西省干细胞工程技术研究中心,杨凌712100 [2]百欧派(天津)生物技术有限公司,天津300350

出　　处：《畜牧兽医学报》2024年第11期4863-4871,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(32072806);百欧派(天津)生物技术有限公司项目(K4040121281)。

摘　　要：全球有相当一部分人群因对猫过敏而受到影响,患者症状小到鼻炎,大到哮喘,甚至呼吸障碍,对过敏患者的生活造成严重影响。Fel d 1是目前公认的主要猫过敏原,是一种分泌型球蛋白,主要产生于猫的皮脂腺和唾液腺,在猫梳理毛发的过程中分布到猫毛上,并最终散播到空气中。为解决人类对猫过敏这一难题,相关研究人员尝试从多条途径减少Fel d 1的分泌或控制其传播,以达到缓解或消除猫过敏患者的过敏反应,如通过清洁猫毛、清洁室内环境、培育低过敏性猫、为猫注射疫苗等方法来实现。本文就猫过敏原的研究进展和对猫过敏的管理控制以及治疗措施进行综述。A significant portion of the global population is affected by allergies to cats,with symptoms ranging from rhinitis to asthma and respiratory disorders,which have a serious impact on the lives of allergy sufferers.Fel d 1 is currently recognized as the main allergen in cats.It is a secretory globulin primarily produced in the sebaceous and salivary glands of cats,distributed onto their fur during grooming and eventually dispersed into the air.To address the challenge of cat allergies in humans,researchers have attempted various approaches to reduce the secretion of Fel d 1 or control its spread.These efforts aim to alleviate or eliminate allergic reactions in cat allergy patients,including methods such as cleaning cat fur,maintaining a clean indoor environment,breeding hypoallergenic cats,and administering vaccines to cats.This paper provides an overview of the research progress on feline allergens,management and control of cat allergies,and treatment measures.

关 键 词：过敏 Fel d 1 症状 管理 治疗 

分 类 号：S852.4[农业科学—基础兽医学] R392.8[农业科学—兽医学]