系统性免疫性炎症指数与急性ST段抬高型心肌梗死患者PCI术后左室重构的关系  

Relationship between systemic immune-inflammation index and left ventricular remodeling in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention

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作  者:金峰 郭兴 祁昊 Jin Feng;Guo Xing;Qi Hao(Department of Cardiology,Henan Chest Hospital of Henan Province,Zhengzhou 450000,China;不详)

机构地区:[1]河南省胸科医院心内科,郑州450000

出  处:《中国循证心血管医学杂志》2024年第11期1350-1352,1357,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基  金:河南省医学科技攻关计划联合共建项目(LHGJ20190738)。

摘  要:目的检测系统性免疫性炎症指数(SII)与急性ST段抬高型心肌梗死患者(STEMI)患者经皮冠状动脉介入治疗(PCI)术后左室重构的关系。方法选取2020年1月至2021年12月于河南省胸科医院心内科住院接受PCI的150例STEMI患者作为STEMI组,另选取本院同期进行体检的150例健康成人为对照组。分析STEMI患者临床资料及PCI术后SII与左室重构的关系。结果与对照组比较,STEMI组患者的SII值显著升高(P<0.05)。随访期间,共有44例患者(29.3%)发生左室重构。将STEMI组患者分为非左室重构组和左室重构组。与非左室重构组患者比较,左室重构组STEMI患者的中性粒细胞计数、血小板计数、血糖、肌酸激酶同工酶(CK-MB)和N末端脑钠肽前体(NT-proBNP)更高,而淋巴细胞计数更低(P<0.05)。与非左室重构组STEMI患者比较,左室重构组STEMI患者的左室收缩末期容积(LVESV)和左室舒张末期容积(LVEDV)显著升高,左室射血分数(LVEF)显著降低(P<0.05)。Person相关分析结果显示,SII与LVESV和LVEDV呈明显的正相关性(P<0.05),与LVEF呈显著负相关(P<0.05)。ROC曲线结果表明,SII预测STEMI患者PCI术后左室重构的AUC为0.861(95%CI:0.819~0.903,P<0.05),敏感性为88.1%,特异性为76.4%。结论SII在预测STEMI患者PCI术后发生左室重构方面具有潜在预测价值。Objective To detect the relationship between systemic immune-inflammation index(SII)and left ventricular remodeling(LVR)in patients with acute ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods STEMI patients undergone PCI were chosen into STEMI group(n=150),and healthy control with physical examinations were chosen into control group(n=150)from Department of Cardiology in Henan Chest Hospital of Henan Province from Jan.2020 to Dec.2021.The clinical materials and relationship between SII and LVR after PCI were analyzed.Results The value of SII increased significantly in STEMI group compared with control group(P<0.05).There were totally 44(29.3%)patients with LVR during follow-up period.The STEMI group was further divided into non-LVR subgroup and LVR subgroup.Compared with non-LVR subgroup,neutrophil count(NEUT),platelet count(PLT),blood sugar,creatine kinase-MB isoenzyme(CK-MB)and N-terminal pro-brain natriuretic peptide(NT-proBNP)were higher,and lymphocyte count was lower(P<0.05),and left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic volume(LVEDV)increased significantly,and left ventricular ejection fraction(LVEF)decreased significantly(P<0.05)in LVR subgroup.The results of Person correlation analysis showed that SII was positively correlated to LVESV and LVEDV significantly(P<0.05),and was negatively correlated to LVEF significantly(P<0.05).The results of ROC curve analysis showed that,in prediction of LVR in STEMI patients after PCI by SII,AUC was 0.861(95%CI:0.819-0.903,P<0.05),sensitivity was 88.1%and specificity was 76.4%.Conclusion SII has a potential predictive value to LVR occurrence in STEMI patients after PCI.

关 键 词:急性心肌梗死 系统性免疫性炎症指数 左室重构 

分 类 号:R542.22[医药卫生—心血管疾病]

 

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