高血压患者血清Apelin-13、SFRP-5水平与冠状动脉病变的关系  

Relationship among apelin-13,secreted frizzled-related protein-1 and coronary artery lesions in patients with hypertension

作　　者：郭娅娅 赵莉[2] 李智[1] Guo Yaya;Zhao Li;Li Zhi(Department of Cardiovascular Medicine,Affiliated Hospital of Yan`an University,Yan'an 716000,China;不详)

机构地区：[1]延安大学附属医院心血管内科,延安716000 [2]延安大学附属医院高血压心衰科,延安716000

出　　处：《中国循证心血管医学杂志》2024年第11期1362-1365,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：陕西省科技计划项目(2019M015)。

摘　　要：目的探讨高血压患者血清爱帕琳肽-13(Apelin-13)、分泌型卷曲相关蛋白-5(SFRP-5)水平与冠状动脉病变的关系。方法选取2021年1月至2023年10月于延安大学附属医院收治的高血压患者175例(高血压组)和同时间段体检健康人群40例(对照组),根据冠状动脉造影结果将高血压患者分为冠状动脉粥样硬化性心脏病(冠心病)组(冠状动脉直径狭窄>50%,53例)、冠状动脉粥样硬化组(冠状动脉直径狭窄>0~50%,66例)、造影正常组(冠状动脉无狭窄,56例)。采用酶联免疫吸附法检测血清Apelin-13、SFRP-5水平。通过多元无序Logistic回归分析高血压患者冠状动脉病变的因素。结果与对照组比较,高血压组患者血清Apelin-13、SFRP-5水平降低(P<0.05)。冠心病组血清Apelin-13、SFRP-5水平低于冠状动脉粥样硬化组、造影正常组,冠状动脉粥样硬化组血清Apelin-13、SFRP-5水平低于造影正常组(P<0.05)。多元无序Logistic回归分析显示,年龄增加、病程延长分别为高血压患者冠状动脉粥样硬化和冠心病的独立危险因素,Apelin-13升高、SFRP-5升高为独立保护因素(P<0.05)。结论高血压病人血清Apelin-13、SFRP-5水平降低,与冠状动脉病变发生及程度密切相关。Objective To investigate the relationship among apelin-13,secreted frizzled-related protein-1(SFRP-1)and coronary artery lesions in patients with hypertension(HTN).Methods The patients with HTN(n=175)were chosen into HTN group and healthy controls(n=40)were chosen into control group from Affiliated Hospital of Yan`an University from Jan.2021 to Oct.2023.The HTN group was divided,according to results of coronary angiography(CAG),into coronary heart disease group(CHD group,n=53),coronary atherosclerosis group(CAS group,n=66)and CAG normal group(n=56).The levels of apelin-13 and SFRP-5 were detected by using enzyme-linked immunosorbent assay(ELISA).The risk factors for coronary artery lesions were analyzed by using multi-factor unordered Logistic regression analysis in HTN patients.Results The levels of apelin-13 and SFRP-5 decreased in HTN group compared with control group(P<0.05).The levels of apelin-13 and SFRP-5 were lower in CHD group than those in CAS group and CAG normal group,and were lower in CAS group than those in CAG normal group(P<0.05).The results of multi-factor unordered Logistic regression analysis showed that increased age and longer disease course were independent risk factors,and increased apelin-13 and SFRP-5 were independent protective factor of CAS and CHD in HTN patients(P<0.05).Conclusion The decreased levels of apelin-13 and SFRP-5 are closely correlated to occurrence and severity of coronary artery lesions in HTN patients.

关 键 词：高血压 爱帕琳肽-13 分泌型卷曲相关蛋白-5 冠状动脉病变 

分 类 号：R544.1[医药卫生—心血管疾病]