Generation of medical isotopes ^(47)Sc,^(67)Cu through laser-induced(γ,p)reaction  

作　　者：Jian-Yao Zhang Di Wu Hao-Yang Lan Huan-Gang Lu Jia-Xin Liu Jian-Feng Lv Mei-Zhi Wang Xue-Qing Yan 

机构地区：[1]State Key Laboratory of Nuclear Physics and Technology,School of Physics,CAPT,Peking University,Beijing 100871,China [2]Beijing Laser Acceleration Innovation Center,Beijing 101407,China

出　　处：《Nuclear Science and Techniques》2024年第11期219-227,共9页核技术（英文）

摘　　要：Short-lived medical isotopes and their generators are typically produced in nuclear reactors and cyclotrons that require extensive facilities.However,considering the environmental concerns and economic costs of these traditional approaches,modern laser technology,which provides extremely strong electric fields within tabletop-sized areas,can serve as a potential supplementary method.Focusing specifically on the(γ,p)generation of the vital medical isotopes^(47)Sc and^(67)Cu,we used both experimental results and PIC-GEANT4 simulations to demonstrate that laser-induced photonuclear reaction is a promising method for isotope production.We developed a model capable of calculating isotope yields under various laser conditions and acceleration mechanisms.The findings revealed that a 200 TW laser can sufficiently produce diagnostic amounts of^(47)Sc and^(67)Cu,while simultaneously providing high specific activity,which is significant in medical applications for improving treatment efficacy,enhancing image resolution,and reducing side effects.

关 键 词：Photonuclear reaction Laser-drivenγ-Ray Medical isotope 

分 类 号：R318[医药卫生—生物医学工程] TL92[医药卫生—基础医学]