Chinese herb pollen derived micromotors as active oral drug delivery system for gastric ulcer treatment  

作　　者：Lijun Cai Cheng Zhao Xinyue Cao Minhui Lu Ning Li Yuan Luo Yongan Wang Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,China [2]State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology and Toxicology,Beijing,100850,China [3]Southeast University Shenzhen Research Institute,Shenzhen,518071,China

出　　处：《Bioactive Materials》2024年第2期28-36,共9页生物活性材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2022YFA1105300);the National Natural Science Foundation of China(T2225003,52073060 and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038).

摘　　要：Considerable efforts have been devoted to treating gastric ulcers.Attempts in this field tend to develop drug delivery systems with prolonged gastric retention time.Herein,we develop novel Chinese herb pollen-derived micromotors as active oral drug delivery system for treating gastric ulcer.Such Chinese herb pollen-derived micromotors are simply produced by asymmetrically sputtering Mg layer onto one side of pollen grains.When exposed to gastric juice,the Mg layer can react with the hydrogen ions,resulting in intensive generation of hydrogen bubbles to propel the micromotors.Benefiting from the autonomous motion and unique spiny structure,our micromotors can move actively in the stomach and adhere to the surrounding tissues.Besides,their special architecture endows the micromotors with salient capacity of drug loading and releasing.Based on these features,we have demonstrated that our Chinese herb pollen-derived micromotors could effective deliver berberine hydrochloride and show desirable curative effect on the gastric ulcer model of mice.Therefore,these Chinese herb pollen-derived micromotors are anticipated to serve as promising oral drug delivery carriers for clinical applications.

关 键 词：MICROMOTOR Chinese herb POLLEN Drug delivery Gastric ulcer Wound healing 

分 类 号：R318[医药卫生—生物医学工程]