High temperature oxidation treated 3D printed anatomical WE43 alloy scaffolds for repairing periarticular bone defects:In vitro and in vivo studies  

作　　者：Bingchuan Liu Jinge Liu Chaoxin Wang Zhengguang Wang Shuyuan Min Caimei Wang Yufeng Zheng Peng Wen Yun Tian 

机构地区：[1]Department of Orthopaedics,Peking University Third Hospital,Beijing,100191,China [2]Engineering Research Center of Bone and Joint Precision Medicine,Ministry of Education,Beijing,100191,China [3]The State Key Laboratory of Tribology,Tsinghua University,Beijing,100084,China [4]Department of Mechanical Engineering,Tsinghua University,Beijing,100084,China [5]Beijing AKEC Medical Co.,Ltd.,Beijing,102200,China [6]School of Materials Science and Engineering,Peking University,Beijing,100871,China

出　　处：《Bioactive Materials》2024年第2期177-189,共13页生物活性材料（英文）

基　　金：funded by the National Key Research and Development Program of China(No.2018YFE0104200);National Natural Science Foundation of China(51875310,52175274,82172065);Peking University Medicine Sailing Program for Young Scholars’Scientific&Technological Innovation(BMU2023YFJHPY015).

摘　　要：Reconstruction of subarticular bone defects is an intractable challenge in orthopedics.The simultaneous repair of cancellous defects,fractures,and cartilage damage is an ideal surgical outcome.3D printed porous anatomical WE43(magnesium with 4 wt%yttrium and 3 wt%rare earths)scaffolds have many advantages for repairing such bone defects,including good biocompatibility,appropriate mechanical strength,customizable shape and structure,and biodegradability.In a previous investigation,we successfully enhanced the corrosion resistance of WE43 samples via high temperature oxidation(HTO).In the present study,we explored the feasibility and effectiveness of HTO-treated 3D printed porous anatomical WE43 scaffolds for repairing the cancellous bone defects accompanied by split fractures via in vitro and in vivo experiments.After HTO treatment,a dense oxidation layer mainly composed of Y2O3 and Nd2O3 formed on the surface of scaffolds.In addition,the majority of the grains were equiaxed,with an average grain size of 7.4μm.Cell and rabbit experiments confirmed the non-cytotoxicity and biocompatibility of the HTO-treated WE43 scaffolds.After the implantation of scaffolds inside bone defects,their porous structures could be maintained for more than 12 weeks without penetration and for more than 6 weeks with penetration.During the postoperative follow-up period for up to 48 weeks,radiographic examinations and histological analysis revealed that abundant bone gradually regenerated along with scaffold degradation,and stable osseointegration formed between new bone and scaffold residues.MRI images further demonstrated no evidence of any obvious damage to the cartilage,ligaments,or menisci,confirming the absence of traumatic osteoarthritis.Moreover,finite element analysis and biomechanical tests further verified that the scaffolds was conducive to a uniform mechanical distribution.In conclusion,applying the HTO-treated 3D printed porous anatomical WE43 scaffolds exhibited favorable repairing effects for subarticular cancellous bone

关 键 词：Periarticular bone defects 3D printing technology Magnesium alloy High temperature oxidation OSSEOINTEGRATION 

分 类 号：TG14[一般工业技术—材料科学与工程] R318[金属学及工艺—金属材料]