Copper ion/gallic acid MOFs-laden adhesive pomelo peel sponge effectively treats biofilm-infected skin wounds and improves healing quality  

作　　者：Jianqiu Yang Zhenzhen Huang Jiang Tan Jingye Pan Shixuan Chen Wenbing Wan 

机构地区：[1]Department of Orthopaedic Surgery,The Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi 330006,China [2]Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang 325000,China [3]Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China [4]Zhejiang Engineering Research Center for Hospital Emergency and Process Digitization,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China

出　　处：《Bioactive Materials》2024年第2期260-276,共17页生物活性材料（英文）

基　　金：financially supported by the National Natural Science Foundation of China(grant no.82102334 to S.Chen,grant no.82272204 to J.Pan,grant no.82360446 to W.Wan);Wenzhou Science and Technology Major Project(grant no.ZY2022026 to S.Chen);Pioneer”and“Leading Goose”R&D Program of Zhejiang(grant no.2023C03084 to J.Pan);Foundation of Health Commission of Jiangxi Province(Grant No.202210603 to W.Wan);the“Thousand Talents Plan”of Jiangxi Province Introduces and Trains Innovative and Entrepreneurial High-level Talents(jxsq2023201027).

摘　　要：Bacterial infection and scar formation remain primary challenges in wound healing.To address these issues,we developed a decellularized pomelo peel(DPP)functionalized with an adhesive PVA-TSPBA hydrogel and antibacterial gallic acid/copper MOFs.The hybrid wound dressing demonstrates favorable biocompatibility.It does not impede the proliferation of fibroblasts or immune cells and can stimulate fibroblast migration,endothelial angiogenesis,and M2 macrophage polarization.Additionally,the dressing can scavenge reactive oxygen species(ROS)and provide antioxidant effects.Furthermore,DPP+MOF@Gel effectively inhibits the viability of S.aureus and E.coli in vitro and in vivo.The histological observations revealed enhanced granulation tissue formation,re-epithelialization,and angiogenesis in the DPP+MOF@Gel group compared to other groups.The local immune response also shifted from a pro-inflammatory to a pro-regenerative status with DPP+MOF@Gel treatment.The skin incision stitching experiment further exhibits DPP+MOF@Gel could reduce scar formation during wound healing.Taken together,the hybrid DPP+MOF@Gel holds great promise for treating bacteria-infected skin wounds and inhibiting scar formation during wound healing.

关 键 词：Wound healing Decellularized pomelo peel Bacteria infection Granulation tissue formation Scar formation 

分 类 号：R318[医药卫生—生物医学工程]