Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application  

作　　者：Tianqi Liu Ying Liu Xiaoyu Zhao Liguo Zhang Wei Wang De Bai Ya Liao Zhenyuan Wang Mi Wang Jiaheng Zhang 

机构地区：[1]State Key Laboratory of Advanced Welding and Joining,School of Materials Science and Engineering,Harbin Institute of Technology(Shenzhen),Shenzhen,518055,China [2]Research Center of Printed Flexible Electronics,School of Materials Science and Engineering,Harbin Institute of Technology,Shenzhen,518055,China [3]Shenzhen Shinehigh Innovation Technology Co.,Ltd.,Shenzhen,518055,China [4]Harbin Voolga Technology Co.,Ltd.,Harbin,150070,China [5]CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China [6]Department of Chemistry,College of Sciences,Northeastern University,Shenyang,110819,China

出　　处：《Bioactive Materials》2024年第2期502-513,共12页生物活性材料（英文）

基　　金：Support was received from the National Natural Science Foundation of China(21703218);Shenzhen Science and Technology Innovation Commission(JCYJ20180507183907224,KQTD20170809110344233);Shenzhen Economic,Trade and Information Commission through the Graphene Manufacturing Innovation Center(201901161514);The Guangdong Provincial Covid-19 Pandemic Control Research Fund(2020KZDZX1220).

摘　　要：Copper peptides(GHK-Cu)are a powerful hair growth promoter with minimal side effects when compared with minoxidil and finasteride;however,challenges in delivering GHK-Cu topically limits their non-invasive applications.Using theoretical calculations and pseudo-ternary phase diagrams,we designed and constructed a thermodynamically stable ionic liquid(IL)-based microemulsion(IL-M),which integrates the high drug solubility of ILs and high skin permeability of microemulsions,thus improving the local delivery of copper peptides by approximately three-fold while retaining their biological function.Experiments in mice validated the effectiveness of our proposed IL-M system.Furthermore,the exact effects of the IL-M system on the expression of growth factors,such as vascular endothelial growth factor,were revealed,and it was found that microemulsion increased the activation of the Wnt/β-catenin signaling pathway,which includes factors involved in hair growth regulation.Overall,the safe and non-invasive IL microemulsion system developed in this study has great potential for the clinical treatment of hair loss.

关 键 词：Bio-based ionic liquids Copper peptides MICROEMULSION Hair regeneration Transdermal delivery 

分 类 号：R318[医药卫生—生物医学工程]