Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease  

作　　者：Chang Liu Weiyi Wang Haoqiang Lai Yikang Chen Lvyi Li Haiwei Li Meixiao Zhan Tianfeng Chen Wenqiang Cao Xiaoling Li 

机构地区：[1]Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan University),Zhuhai,519000,PR China [2]Zhuhai Jinan Selenium Source Nanotechnology Co.,Ltd,Jinan University,Zhuhai 519000,China [3]Department of Chemistry,Institute of Food Safety and Nutrition,Jinan University,Guangzhou 510632,China [4]Guangdong Jinan Established Selenium Source Nano Technology Research Institute Co.,Ltd.,Guangzhou 510535,China

出　　处：《Bioactive Materials》2024年第7期393-406,共14页生物活性材料（英文）

基　　金：supported by the National Science Fund for Distinguished Young Scholars (82225025);National Natural Science Foundation of China (21877049,32171296,32101044);Guangdong Natural Science Foundation (2020B1515120043);K.C.Wong Education Foundation and China Postdoctoral Science Foundation (2022M711341).

摘　　要：Radiation-induced heart disease(RIHD),characterized by severe oxidative stress and immune dysregulation,is a serious condition affecting cancer patients undergoing thoracic radiation.Unfortunately,clinical interventions for RIHD are lacking.Selenium(Se)is a trace element with excellent antioxidant and immune-modulatory properties.However,its application in heart radioprotection remains challenging.Herein,we developed a novel bioactive Cordyceps militaris-based Se oral delivery system(Se@CM),which demonstrated superior radioprotection effects in vitro against X-ray-induced damage in H9C2 cells through suppressing excessive ROS generation,compared to the radioprotectant Amifostine.Moreover,Se@CM exhibited exceptional cardioprotective effects in vivo against X-ray irradiation,reducing cardiac dysfunction and myocardial fibrosis by balancing the redox equilibrium and modulating the expression of Mn-SOD and MDA.Additionally,Se@CM maintained immuno-homeostasis,as evidenced by the upregulated population of T cells and M2 macrophages through modulation of selenoprotein expression after irradiation.Together,these results highlight the remarkable antioxidant and immunity modulation properties of Se@CM and shed light on its promising application for cardiac protection against IR-induced disease.This research provides valuable insights into developing effective strategies for preventing and managing RIHD.

关 键 词：Radiation-induced heart disease Antioxidant SELENIUM SELENOPROTEIN Heart protection 

分 类 号：R541[医药卫生—心血管疾病]