Hydrogel for light delivery in biomedical applications  

作　　者：Pek Yin Michelle Yew Pei Lin Chee Qianyu Lin Cally Owh Jiayi Li Qing Qing Dou Xian Jun Loh Dan Kai Yong Zhang 

机构地区：[1]Institute of Sustainability for Chemicals,Energy and Environment(ISCE2),Agency for Science,Technology and Research(A*STAR),1 Pesek Road,627833,Singapore [2]Department of Biomedical Engineering,Faculty of Engineering,National University of Singapore,Singapore,117583,Singapore [3]Institute of Materials Research and Engineering(IMRE),Agency for Science,Technology and Research(A*STAR),2 Fusionopolis Way,Innovis#08-03,Singapore,138634,Singapore [4]School of Biological Sciences,Nanyang Technological University,60 Nanyang Drive,Singapore,637551,Singapore [5]School of Environmental and Chemical Engineering,Shanghai University,Shanghai,200444,China [6]School of Chemistry,Chemical Engineering and Biotechnology,Nanyang Technological University,21 Nanyang Link,Singapore,637371,Singapore [7]Department of Biomedical Engineering,City University of Hong Kong,83 Tat Chee Avenue,Kowloon,Hong Kong SAR,China

出　　处：《Bioactive Materials》2024年第7期407-423,共17页生物活性材料（英文）

基　　金：supported by the RIE2025 MTC Individual Research Grants (M22K2c0085)and Central Research Fund,administered by the Agency of Science,Technology and Research (A*STAR);supported by National Research Foundation (NRF)Singapore under its NRF Investigatorship (NRF-NRFI07-2021-0003);supported by the National Medical Research Council (NMRC),Singapore,under its Clinician Scientist-Individual Research Grant (CS-IRG)[MOH-001357-00].

摘　　要：Traditional optical waveguides or mediums are often silica-based materials,but their applications in biomedicine and healthcare are limited due to the poor biocompatibility and unsuitable mechanical properties.In term of the applications in human body,a biocompatible hydrogel system with excellent optical transparency and mechanical flexibility could be beneficial.In this review,we explore the different designs of hydrogel-based optical waveguides derived from natural and synthetic sources.We highlighted key developments such as light emitting contact lenses,implantable optical fibres,biosensing systems,luminating and fluorescent materials.Finally,we expand further on the challenges and perspectives for hydrogel waveguides to achieve clinical applications.

关 键 词：Optical fibres Transparent hydrogels FLEXIBILITY BIOCOMPATIBILITY Photodynamic therapy 

分 类 号：TQ427.26[化学工程] R318[医药卫生—生物医学工程]