术前联用间苯三酚与坦索罗辛对输尿管镜手术影响的研究  

Study on the effect of preoperative combined use of phloroglucinol and tamsulosin on ureteroscopic surgery

作　　者：简月晃 谢明 周航 吴石萍 JIAN Yuehuang;XIE Ming;ZHOU Hang;WU Shiping(Department of Urology,Third People's Hospital of Pingxiang City,Pingxiang,Jiangxi,337000,China)

机构地区：[1]萍乡市第三人民医院泌尿外科,江西萍乡337000

出　　处：《当代医学》2024年第17期121-124,共4页Contemporary Medicine

基　　金：萍乡市科技计划项目(2020PY101)。

摘　　要：目的分析术前联用间苯三酚、坦索罗辛对输尿管镜手术的影响。方法选取2020年5月至2021年12月于萍乡市第三人民医院行输尿管镜手术的80例患者作为研究对象,按照治疗方法不同分为参照组(n=39,常规输尿管镜手术)与实验组(n=41,输尿管镜手术术前增加间苯三酚、坦索罗辛治疗)。比较两组手术相关指标、炎症因子、肾功能指标、术后并发症和药物不良反应发生情况。结果实验组手术时间短于参照组,术后24 h视觉模拟评分法(visual analogue scale,VAS)评分低于参照组,结石清除率和一次性进镜成功率均高于参照组,差异有统计学意义(P<0.05)。术后当天、术后3 d,实验组高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、血尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,SCr)水平及WBC均低于参照组,红细胞计数(red blood cell count,RBC)高于参照组,差异有统计学意义(P<0.05)。两组药物不良反应发生率比较差异无统计学意义,实验组并发症发生率低于参照组,差异有统计学意义(P<0.05)。结论输尿管镜手术前采用间苯三酚、坦索罗辛治疗可缩短手术时间,提高结石清除效果和进镜成功率,缓解术后疼痛,降低相关并发症发生风险,且药物安全性较高。Objective To analyze the effect of preoperative combined use of phloroglucinol and tamsulosin on ureteroscopic surgery.Methods 80 patients who underwent ureteroscopic surgery at the Third People's Hospital of Pingxiang City from January 2021 to December 2021 were selected as the study subjects,they were divided into the control group(n=39,conventional ureteroscopic surgery)and the experimental group(n=41,phloroglucinol addition of meta phenylenetriazole and tamsulosin treatment)according to the different treatment method.The operation related indexes,inflammatory factors,renal function indexes,postoperative complications and adverse drug reactions were compared between the two groups.Results The operation time in the experimental group was shorter than that in the reference group,and the visual analogue scale score at 24 h after operation was lower than that in the reference group,the stone clearance rate and the success rate of one-time insertion were higher than those in the reference group,and the differences were statistically significant(P<0.05).1 and 3 d after operation,the levels of high-sensitivity C-reactive protein(hs-CRP),blood urea nitrogen(BUN),serum creatinine(SCr)and WBC in the experimental group were lower than those in the reference group,the red blood cell(RBC)count was higher than that in the reference group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups,the incidence of complications in the experimental group was lower than that in the reference group,and the difference was statistically significant(P<0.05).Conclusion The use of phloroglucinol and tamsulosin before ureteroscopic surgery can shorten the operation time,improve the stone removal effect and the success rate of entering the ureteroscope,relieve postoperative pain,reduce the risk of related complications,and have high drug safety.

关 键 词：输尿管镜手术 间苯三酚 结石 坦索罗辛 

分 类 号：R699[医药卫生—泌尿科学]