血清丙氨酸氨基转移酶在慢性乙型肝炎中的表达及其对抗病毒疗效的评估作用  

Expression of serum alanine aminotransferase in chronic hepatitis B and its role in the assessment of antiviral efficacy

作　　者：赵华 ZHAO Hua(Department of Spleen and Stomach Diseases,DonggangTraditional Chinese Medicine Hospital,Dandong,Liaoning,118300,China)

机构地区：[1]东港市中医院脾胃病科,辽宁丹东118300

出　　处：《当代医学》2024年第17期172-174,共3页Contemporary Medicine

摘　　要：目的分析血清丙氨酸氨基转移酶(alanine aminotransferase,ALT)在慢性乙型肝炎中的表达及其对抗病毒疗效的评估作用。方法选取2017年1月至2019年6月东港市中医院收治的80例慢性乙型肝炎患者作为研究对象,根据治疗前基线血清ALT水平分为正常组(n=8)、升高组(n=48)及显著升高组(n=24)。3组均给予恩替卡韦治疗,比较3组治疗前后ALT水平、治疗后应答、乙肝病毒的脱氧核糖核酸(hepatitis B virus DNA,HBV-DNA)lg值下降情况、临床疗效。结果治疗前,3组ALT水平比较差异有统计学意义(P<0.05),显著升高组ALT水平高于升高组和正常组,升高组高于正常组,差异有统计意义(P<0.05);治疗后,3组ALT水平低于治疗前,差异有统计意义(P<0.05),3组间ALT水平比较差异无统计学意义。3组HBV-DNA转阴率、乙型肝炎e抗原(hepatitis B e antigen,HBeAg)转阴率、HBeAg血清转换率、血清ALT复常率比较差异无统计学意义。随访12、24周,显著升高组HBV-DNA下降值高于正常组和升高组,且升高组高于正常组,差异有统计学意义(P<0.05);随访48周,3组HBV-DNA下降值比较差异无统计学意义。3组治疗总有效率比较差异无统计学意义。结论慢性乙型肝炎患者血清ALT水平以高表达为主,且血清ALT水平不影响抗病毒疗效。Objective To analyze the expression of serum alanine aminotransferase(ALT)in chronic hepatitis B and its role in the assessment of antiviral efficacy.Methods 80 patients with chronic hepatitis B admitted to the DonggangTraditional Chinese Medicine Hospital from January 2017 to June 2019 were selected as the research subjects,patients were classified into the normal group(n=8),the mildly elevated group(n=48)and the severely elevated group(n=24)according to their baseline serum ALT level.All the three groups were treated with entecavir,the ALT level,response to treatment,decrease of hepatitis B virus deoxy-ribonucleic acid(HBV-DNA)1g viral load and clinical efficacy were compared among three groups.Results Before treatment,there was significant difference in ALT level among the three groups(P<0.05),the ALT level in the severely elevated group was higher than that in the mildly elevated group and the normal group,and the elevated group was higher than that in the normal group,the differences were statistically significant(P<0.05).After treatment,ALT level in the three groups was lower than before treatment,the difference was statistically significant(P<0.05),but there was no significant difference in ALT level among the three groups.There were no significant differences in HBV-DNA negative conversion rate,hepatitis B e antigen(HBeAg)negative conversion rate,HBeAg serum conversion rate and serum ALT normalizing rate among the three groups.After 12 and 24 weeks of follow-up,the decrease value of HBV-DNA in the severely elevated group were higher than those in the normal group and the mildly elevated group,and the mildly elevated group was higher than that in the normal group,the differences were statistically significant(P<0.05);after 48 weeks of follow-up,there was no significant difference in HBV-DNA decline among the three groups.There was no significant difference in the total effective rate among the three groups.Conclusion The serum ALT level of chronic hepatitis B patients is mainly high expression,and the seru

关 键 词：丙氨酸氨基转移酶 慢性乙型肝炎 抗病毒 疗效 

分 类 号：R512.62[医药卫生—内科学]