硬化蛋白(sclerostin)在软骨代谢与骨关节疾病中的分子机制研究进展  

Research progress on the role of sclerostin in cartilage metabolism,development,and related bone and joint disease mechanisms

作　　者：冯琳 丰哲[2] 陶奕孜 魏纪湖 吕和 鲁世金[3] FENG Lin;FENG Zhe;TAO Yizi;WEI Jihu;Lv He;LU Shijin(Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;Department of Arthrology,Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530011,China;Integrated Traditional Chinese and Western Medicine Translational Medicine Center of Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530011,China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学附属瑞康医院关节科,广西南宁530011 [3]广西中医药大学附属瑞康医院中西医结合转化医学中心,广西南宁530011

出　　处：《海南医学院学报》2024年第22期1744-1750,共7页Journal of Hainan Medical University

基　　金：国家自然科学基金资助项目(82260944);广西重点研发计划(2021AB09011)。

摘　　要：硬化蛋白(SOST基因编码蛋白)是一种分泌型跨膜糖蛋白,在骨骼发育与骨矿物质密度(BMD)调节过程中发挥着关键作用,主要由关节软骨中的软骨细胞和软骨下骨中的骨细胞表达。在骨形成过程中,SOST通过抑制Wnt信号通路,调节炎症诱导的软骨代谢,发挥了关键的调控作用。本文从硬化蛋白与其调控基因SOST在关节软骨发育中的作用出发,对硬化蛋白参与关节疾病发展的相关机制进行综述,并探讨其作为关节软骨防治的分子及其在临床应用中的前景。Sclerosing protein(SOST gene encoded protein)is a secreted transmembrane glycoprotein that plays a crucial role in bone development and bone mineral density(BMD)regulation.It is mainly expressed by chondrocytes in articular cartilage and bone cells in subchondral bone.During bone formation,SOST plays a crucial regulatory role by inhibiting the Wnt signaling pathway and regulating inflammation induced cartilage metabolism.Starting from the role of sclerotin and its regulatory gene SOST in the development of articular cartilage,this article reviews the relevant mechanisms of sclerotin's involvement in the development of joint diseases,and explores its potential as a molecule for the prevention and treatment of articular cartilage and its clinical applications.

关 键 词：硬化蛋白(SOST) 软骨 骨关节炎 研究进展 

分 类 号：R68[医药卫生—骨科学]