间充质干细胞源性外泌体在改善病理性瘢痕中作用的研究进展  

Research progress on the role of stem cell-derived exosomes in improving pathological cicatrix

作　　者：宋勤琴 李双汝 李林 杜鹃 刘继松[1] Song Qinqin;Li Shuangru;Li Lin;Du Juan;Liu Jisong(Department of Burns and Plastic Surgery,the Third People′s Hospital of Bengbu Affiliated to Bengbu Medical University,Bengbu 233000,China)

机构地区：[1]蚌埠医科大学附属蚌埠市第三人民医院烧伤整形科,233000

出　　处：《中华损伤与修复杂志（电子版）》2024年第6期550-553,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：安徽省高等学校科学研究项目(2024AH051206);蚌埠市卫生健康委科研项目(BBWK2323A101);蚌埠市科技创新指导类项目(BBKC2023a118)。

摘　　要：病理性瘢痕是整形外科的一种常见疾病,通常分为增生性瘢痕和瘢痕疙瘩,其形成可能导致皮肤组织的增生和纤维化。病理性瘢痕的形成是一个极其复杂的过程,主要是由于细胞外基质(ECM)在伤口愈合过程中过度沉积。病理性瘢痕由于外观畸形、瘙痒、疼痛和运动障碍而导致患者生活质量和心理健康受损,但目前还没有明确消除瘢痕的治疗方法。研究发现间充质干细胞来源的外泌体在病理性瘢痕形成和发展中具有潜在影响。本文就间充质干细胞源性外泌体在抗炎、促进血管生成、调节基质重塑等方面改善病理性瘢痕的作用机制,以及当前面临的挑战和未来的发展作一综述。Pathological cicatrix is common in plastic surgery and is usually categorized as hypertrophic scarring and keloids,the formation of which may result in hyperplasia and fibrosis of skin tissue.However,the formation of pathological scarring is an extremely complex process,mainly due to the excessive deposition of extracellular matrix(ECM)during wound healing.Pathological cicatrix leads to impaired quality of life and psychological well-being due to cosmetic deformities,itching,pain,and dyskinesia,but there are no definitive treatments to eliminate cicatrix.Stem cell-derived exosomes have potential influence as novel extracellular vesicles in scar formation and development.This paper is a review of the research progress of stem cell-derived exosomes in pathological cicatrix,including the mechanism of action in antiinflammatory effects,promotion of angiogenesis,and regulation of matrix remodeling for improving pathological cicatrix,as well as the current challenges and future directions.

关 键 词：成纤维细胞 干细胞 外泌体 病理性瘢痕 胶原蛋白 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]