Impact of COVID-19-related nonpharmaceutical interventions on diarrheal diseases and zoonotic Salmonella  

作　　者：Linlin Huang Haiyang Zhou Jiaqi Chen Chenghao Jia Abubakar Siddique Beibei Wu Haoqiu Wang Biao Tang Fang He Guoping Zhao Min Yue 

机构地区：[1]Department of Veterinary Medicine,Zhejiang University College of Animal Sciences,Zhejiang,China [2]Hainan Institute of Zhejiang University,Hainan,China [3]Zhejiang Provincial Center for Disease Control and Prevention,Zhejiang,China [4]Hangzhou Center for Disease Control and Prevention,Zhejiang,China [5]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Zhejiang,China [6]ZJU-Xinchang Joint Innovation Centre(TianMu Laboratory),Gaochuang Hi-Tech Park,Zhejiang,China [7]CAS Key Laboratory of Synthetic Biology,Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,China [8]Department of Microbiology and Microbial Engineering,School of Life Sciences,Fudan University,Shanghai,China [9]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,National Medical Center for Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Zhejiang,China

出　　处：《hLife》2024年第5期246-256,共11页健康科学（英文）

基　　金：We would like to thank Annemieke van den Dool(Duke Kunshan University)for the critical reading of the manuscript;This study was supported by the National Program on the Key Research Project of China(2022YFC2604201);the European Union’s Horizon 2020 Research and Innovation Programme(861917-SAFFI);Zhejiang Provincial Key R&D Program of China(2023C03045;2022C02024);Zhejiang Provincial Naturaal Science Foundation of China(LZ24C180002);Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Techonology City(2021JJLH0083).

摘　　要：Non-pharmaceutical interventions(NPIs)have been proven effective in reducing the spread of the coronavirus disease 2019(COVID-19),but their broader impact on gastrointestinal disorders remains poorly studied.Here,we report an observational analysis and retrospective study that compares the incidence of acute diarrheal diseases in Hangzhou,Zhejiang,China,between 2019 and 2020,with an examination of the antimicrobial resistance and genetic spectrum of non-typhoidal Salmonella(NTS)from 2015 to 2022,before and during the COVID-19 pandemic.Our findings underscore that NPIs related to COVID-19 effectively reduced the incidence of acute diarrhea,with a substantial decrease in most enteric pathogens.Notably,NTS exhibited an unexpected surge.Further genomic investigations of NTS isolates revealed an overall reduction in antimicrobial-resistant(AMR),disinfection-tolerant,and virulent capabilities,but with marked variations detected between human and animal isolates.Additional genome-based analysis confirmed a decrease in the scale of zoonotic transmission in response to NPIs,suggesting particular NTS types may contribute to human infections via alternative pathways.The collective findings manifested that COVID-19-related NPIs had a mixed impact on NTS infections,which may inform AMR NTS mitigation policy.

关 键 词：coronavirus disease 2019(COVID-19) non-pharmaceutical interventions(NPIs) non-typhoidal Salmonella(NTS) zoonotic transmission 

分 类 号：R535[医药卫生—内科学]