TLR5 expression marks brain boarder associated macrophages and protects neonatal mice from bacterial meningitis  

作　　者：Deshan Ren Zijian Zhang Xiangkuan Zheng Chun Lu Yuxian Song Shuang Liu Shuai Ding Wei Zhang Yayi Hou Yan Li 

机构地区：[1]National Resource Center for Mutant Mice,MOE Key Laboratory of Model Animals for Disease Study,State Key Laboratory of Pharmaceutical Biotechnology,Medical School of Nanjing University,Jiangsu,China [2]Chemistry and Biomedicine Innovation Center(ChemBIC),Nanjing University,Jiangsu,China [3]College of Veterinary Medicine,Nanjing Agricultural University,Jiangsu,China [4]Central Laboratory of Stomatology,Nanjing Stomatological Hospital,Medical School of Nanjing University,Jiangsu,China [5]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Jiangsu,China [6]Jiangsu Key Laboratory of Molecular Medicine,Medical School of Nanjing University,Nanjing University,Jiangsu,China

出　　处：《hLife》2024年第7期371-376,共6页健康科学（英文）

基　　金：supported by grants from the National Key Research and Development Program of China(2019YFA0802900);National Natural Science Foundation of China(32122035,32000669,32070942);a Jiangsu Provincial Science and Technology Plan Special Fund(BK20232018).

摘　　要：Meningitis is one of the major threats to prenatal and newborn babies,causing more than 300,000 infant deaths worldwide annually.Survivors often suffer from long-term neuron-developmental disorders caused by the infection[1–3].Bacterial meningitis,a prevalent form of this condition,remains a major global public health challenge,despite significant progress in combating specific pathogens[4].In infants,where systemic adaptive immunity is not fully developed,brain macrophage plays a crucial role in defensing pathogen infection in this vital organ[5,6].However,our understanding of the precise markers that reflect the distinct contributions of various macrophage populations in the neonatal brain remains incomplete.

关 键 词：NEONATAL MENINGITIS immunity 

分 类 号：R378.15[医药卫生—病原生物学]